SynthesisDiabetologia2015
The effect of anaemia and abnormalities of erythrocyte indices on HbA1c analysis: a systematic review.
Synthesis in Diabetologia, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 106 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
106 citing papers in PubMed, 3 syntheses or guidelines pooled it, 230 citations in OpenAlex.
- Interference of iron deficiency in glycated hemoglobin testing and its clinical implications: a systematic review and meta-analysis.Biochemia medica · 2026Pooled it
- Stress hyperglycemia ratio in coronary artery disease: a systematic review and meta-analysis of severity and prognosis.Cardiovascular diabetology · 2026Pooled it
- Pooled it
- Impact of Simultaneous Initiation of Finerenone and Empagliflozin on Albuminuria Irrespective of Baseline HbA1c Levels: A Participant-Level Exploratory Analysis of the Randomised CONFIDENCE Trial.Diabetes, obesity & metabolism · 2026Trial
- Influence of red blood cell indices on HbA1c performance in detecting dysglycaemia in a Singapore preconception cohort study.Scientific reports · 2021Trial
- Prevalence and co-existence of cardiometabolic risk factors and associations with nutrition-related and socioeconomic indicators in a national sample of Gambian women.Scientific reports · 2021Trial
- Association between glycated hemoglobin and hematological parameters in patients with type 2 diabetes mellitus: a cross-sectional study.Clinics (Sao Paulo, Brazil) · 2026Article
- Prehabilitation for Patients Undergoing Breast Reduction Surgery: A Scoping Review.Plastic and reconstructive surgery. Global open · 2026Article
- Review
- Methodological Considerations Regarding the Combined Use of Erectile Dysfunction and Frontal QRS-T Angle for Predicting Coronary Artery Disease Severity.Anatolian journal of cardiology · 2026Article
- Markedly Discordant and Rapidly Changing Hemoglobin A1c Values in a Normoglycemic Patient: A Case Report.Cureus · 2026Article
- Interpretable Machine Learning to Predict Metformin-Induced Vitamin B12 Deficiency: Association with Glycemic Control and Neuropathic Symptoms.Metabolites · 2026Article
- Stress hyperglycemia ratio predicts adverse outcomes in emergency department patients with upper gastrointestinal bleeding.PloS one · 2026Article
- Article
- Higher HbA1c-Hemoglobin Ratio Was Associated With Poor Outcome in Endovascular Thrombectomy Patients.Behavioural neurology · 2026Article
- Glycemic assessment when hemoglobin A1c is unreliable: a clinical-laboratory framework for kidney disease, anemia, and hemoglobinopathies.Frontiers in endocrinology · 2026Review
- Critical Relationship Between Iron Deficiency Anaemia (IDA) and Glycated Haemoglobin (HbA1c): An Updated Review.Mini reviews in medicinal chemistry · 2026Review
- The additive effect of hemoglobin glycation index and glycemic variability to predict mortality in cardiac intensive care patients with and without diabetes.Scientific reports · 2025Article
- Glucose 6-phosphate dehydrogenase deficiency and Southeast Asian-specific mutations lower HbADiabetologia · 2025Article
- Pancreatic extracellular volume fraction based on dual-energy computed tomography iodine maps: association with diabetes.Quantitative imaging in medicine and surgery · 2025Article
46 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on by
Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aims/hypothesisThe use of HbA1c for the diagnosis of diabetes is now widely advocated despite caveats to its use. Anaemia is cited as a major confounder to this use; however, the effect of erythrocyte indices and to what degree anaemia influences HbA1c levels is not known.
methodsA systematic electronic database search of MEDLINE, EMBASE, the Cumulative Index to Nursing & Allied Health Literature (CINAHL) and the Cochrane Library was conducted for relevant articles published between January 1990 and May 2014. Included studies had at least one measurement of HbA1c and glucose, and a least one index of haematinic deficiency, involving non-pregnant adults, not known to have diabetes.
resultsA total of 12 articles from 544 were included. The majority of studies focused on iron deficiency anaemia (IDA) and, in general, demonstrated that the presence of iron deficiency with or without anaemia led to an increase in HbA1c values compared with controls, with no concomitant rise in glucose indices. Data on the effects of other indices of erythrocyte abnormalities on HbA1c are limited but show a possible decrease in HbA1c values with non-iron deficiency forms of anaemia. CONCLUSIONS/
interpretationHbA1c is likely to be affected by iron deficiency and IDA with a spurious increase in HbA1c values; conversely, non-IDA may lead to a decreased HbA1c value. This may lead to confusion when diagnosing diabetes using HbA1c. This review clearly identifies the need for more evidence, especially in identifying the types and degrees of anaemia likely to have significant impact on the reliability of HbA1c.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.