ArticleBiology letters2015
Host age modulates within-host parasite competition.
Article in Biology letters, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
14 citing papers in PubMed, 30 citations in OpenAlex.
- Transcriptomic Landscape Reveals Immunity Related Trade-Offs in an Invertebrate-Fungal Host-Parasite System.Molecular ecology · 2026Article
- Microsporidian coinfection reduces fitness of a fungal pathogen due to rapid host mortality.mBio · 2024Article
- Inconsistent dilution: experimental but not field evidence for a dilution effect in Daphnia-bacteria interactions.Oecologia · 2024Article
- Guild Dynamics and Pathogen Interactions inTransboundary and emerging diseases · 2024Article
- The parasites of my rival are my friends.Frontiers in microbiology · 2023Article
- Age-related response to mite parasitization and viral infection in the honey bee suggests a trade-off between growth and immunity.PloS one · 2023Article
- Review
- New monogeneans from the bathydemersal southern African endemic catshark, Holohalaelurus regani (Gilchrist, 1922).Systematic parasitology · 2021Article
- Sequential co-infections drive parasite competition and the outcome of infection.The Journal of animal ecology · 2020Article
- The influence of related and unrelated co-infections on parasite dynamics and virulence.Oecologia · 2018Article
- Parasite-associated mortality in a long-lived mammal: Variation with host age, sex, and reproduction.Ecology and evolution · 2017Article
- The impact of host sex on the outcome of co-infection.Scientific reports · 2017Article
- Disease spread in age structured populations with maternal age effects.Ecology letters · 2017Article
- Costs of resistance and infection by a generalist pathogen.Ecology and evolution · 2016Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In many host populations, one of the most striking differences among hosts is their age. While parasite prevalence differences in relation to host age are well known, little is known on how host age impacts ecological and evolutionary dynamics of diseases. Using two clones of the water flea Daphnia magna and two clones of its bacterial parasite Pasteuria ramosa, we examined how host age at exposure influences within-host parasite competition and virulence. We found that multiply-exposed hosts were more susceptible to infection and suffered higher mortality than singly-exposed hosts. Hosts oldest at exposure were least often infected and vice versa. Furthermore, we found that in young multiply-exposed hosts competition was weak, allowing coexistence and transmission of both parasite clones, whereas in older multiply-exposed hosts competitive exclusion was observed. Thus, age-dependent parasite exposure and host demography (age structure) could together play an important role in mediating parasite evolution. At the individual level, our results demonstrate a previously unnoticed interaction of the host's immune system with host age, suggesting that the specificity of immune function changes as hosts mature. Therefore, evolutionary models of parasite virulence might benefit from incorporating age-dependent epidemiological parameters.
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