ArticlePloS one2015
Cervical microbiota in women with preterm prelabor rupture of membranes.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed, 68 citations in OpenAlex.
- Probiotic ice cream influences gut and vaginal microbiota in women at high risk of preterm birth: a randomized controlled study.Maternal health, neonatology and perinatology · 2025Article
- Does the Vaginal Microbiota Influence the Incidence of the Preterm Premature Rupture of Membranes?Journal of clinical medicine · 2025Review
- The role of amniotic epithelial cells in preterm birth: mechanisms and clinical implications.Frontiers in cell and developmental biology · 2025Review
- Article
- Vaginal Microbial Colonization after Antibiotic Treatment in Women with Preterm Premature Rupture of Membranes: An Observational Cohort Study.Journal of clinical medicine · 2023Article
- The Female Reproductive Tract Microbiota: Friends and Foe.Life (Basel, Switzerland) · 2023Review
- The Role of Neutrophils in Pregnancy, Term and Preterm Labour.Life (Basel, Switzerland) · 2022Review
- Microbiome Diversity in Vaginal Fluid and Sensitivity Patterns in Preterm Premature Rupture of Membrane Cases.Cureus · 2022Article
- Research of cervical microbiota alterations with human papillomavirus infection status and women age in Sanmenxia area of China.Frontiers in microbiology · 2022Article
- Alterations in the vaginal microbiota of patients with preterm premature rupture of membranes.Frontiers in cellular and infection microbiology · 2022Article
- CanPolish journal of microbiology · 2021Article
- Article
- Severe preeclampsia is associated with a higher relative abundance of Prevotella bivia in the vaginal microbiota.Scientific reports · 2020Article
- Tumor microbial diversity and compositional differences among women in Botswana with high-grade cervical dysplasia and cervical cancer.International journal of gynecological cancer : official journal of the International Gynecological Cancer Society · 2020Article
- Lactobacilli-dominated cervical microbiota in women with preterm prelabor rupture of membranes.Pediatric research · 2020Article
- Midtrimester microbial DNA variations in maternal serum of women who experience spontaneous preterm birth.The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians · 2020Article
- Recent advances in cultivation-independent molecular-based techniques for the characterization of vaginal eubiosis and dysbiosis.Faculty reviews · 2020Review
- Characterization of vaginal microbiota in women with preterm labor with intra-amniotic inflammation.Scientific reports · 2019Observational
- The Vaginal Community State Types Microbiome-Immune Network as Key Factor for Bacterial Vaginosis and Aerobic Vaginitis.Frontiers in microbiology · 2019Article
- Vaginal dysbiosis increases risk of preterm fetal membrane rupture, neonatal sepsis and is exacerbated by erythromycin.BMC medicine · 2018Article
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo analyze the cervical microbiota in women with preterm prelabor rupture of membranes (PPROM) by pyrosequencing and to document associations between cervical microbiota, cervical inflammatory response, microbial invasion of the amniotic cavity (MIAC), histological chorioamnionitis, and intraamniotic infection (IAI). STUDY
designSixty-one women with singleton pregnancies complicated by PPROM were included in the study. Specimens of cervical and amniotic fluid were collected on admission. The cervical microbiota was assessed by 16S rRNA gene sequencing by pyrosequencing. Interleukin (IL)-6 concentration in the cervical fluid and amniotic fluid was measured by ELISA and lateral flow immunoassay, respectively.
resultsFour bacterial community state types [CST I (Lactobacillus crispatus dominated), CST III (Lactobacillus iners dominated), CST IV-A (non-Lactobacillus bacteria dominated), and CST IV-B (Gardnerella vaginalis and Sneathia sanguinegens dominated)] were observed in the cervical microbiota of women with PPROM. Cervical fluid IL-6 concentrations differed between CSTs (CST I = 145 pg/mL, CST III = 166 pg/mL, CST IV-A = 420 pg/mL, and CST IV-B = 322 pg/mL; p = 0.004). There were also differences in the rates of MIAC, of both MIAC and histological chorioamnionitis, and of IAI among CSTs. No difference in the rate of histological chorioamnionitis was found among CSTs.
conclusionsThe cervical microbiota in PPROM women in this study was characterized by four CSTs. The presence of non-Lactobacillus CSTs was associated with a strong cervical inflammatory response and higher rates of MIAC, both MIAC and histological chorioamnionitis, and IAI representing a PPROM subtype with pronounced inflammation. CST I represents the dominant type of PPROM with a low rate of MIAC, IAI, and the combination of MIAC and histological chorioamnionitis.
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