ReviewHormones and behavior2015
The evolving role of dendritic spines and memory: Interaction(s) with estradiol.
Review in Hormones and behavior, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 69 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
69 citing papers in PubMed, 150 citations in OpenAlex.
- Exogenous estradiol modulates entorhinal cortex contributions to episodic encoding of conditioned threat in women.Psychoneuroendocrinology · 2026Trial
- Androgen treatment effects on hippocampus structure in boys with Klinefelter syndrome.Psychoneuroendocrinology · 2019Trial
- Elevated plasma sex hormone-binding globulin (SHBG) is associated with reduced temporal lobe volume and cognitive impairment in individuals with mild cognitive impairment.European geriatric medicine · 2026Article
- Menstrual cycle modulates the effect of BDNF Val66Met variant on category learning.Biology of sex differences · 2026Article
- Article
- Androgens Enhance Recognition Memory and Dendritic Spine Density in the Hippocampus and Prefrontal Cortex of Ovariectomized Female Rats.Neuroscience · 2025Article
- Dendritic Morphology of Developing Hippocampal Neurons in Cyp11a1 Null Mice.Developmental neuroscience · 2025Article
- Sex differences in anxiety and depression: insights from adult rodent models of chronic stress and neural plasticity.Frontiers in behavioral neuroscience · 2025Review
- Exploring β-caryophyllene: a non-psychotropic cannabinoid's potential in mitigating cognitive impairment induced by sleep deprivation.Archives of pharmacal research · 2025Review
- Association between finasteride with subjective memory deficits: a study from the NHANES and FAERS databases.Frontiers in neurology · 2025Article
- Treadmill exercise prevents recognition memory impairment in VD rat model and enhancement of hippocampal structural synaptic plasticity.Brain and behavior · 2024Article
- Comprehensive software suite for functional analysis and synaptic input mapping of dendritic spines imagedNeurophotonics · 2024Article
- CYP46A1-mediated cholesterol turnover induces sex-specific changes in cognition and counteracts memory loss in ovariectomized mice.Science advances · 2024Article
- Learning exceptions to category rules varies across the menstrual cycle.Scientific reports · 2023Article
- Hyaluronic Acid Conjugated with 17β-Estradiol Effectively Alleviates Estropause-Induced Cognitive Deficits in Rats.International journal of molecular sciences · 2023Article
- Activation of Gq-Coupled Receptors in Astrocytes Restores Cognitive Function in Alzheimer's Disease Mice Model.International journal of molecular sciences · 2023Article
- Sex differences in synaptic plasticity underlying learning.Journal of neuroscience research · 2023Review
- Complexity of Sex Differences and Their Impact on Alzheimer's Disease.Biomedicines · 2023Review
- Article
- Elevated Hippocampal CRMP5 Mediates Chronic Stress-Induced Cognitive Deficits by Disrupting Synaptic Plasticity, Hindering AMPAR Trafficking, and Triggering Cytokine Release.International journal of molecular sciences · 2023Article
9 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
This article is part of a Special Issue "Estradiol and Cognition". Memory processing is presumed to depend on synaptic plasticity, which appears to have a role in mediating the acquisition, consolidation, and retention of memory. We have studied the relationship between estrogen, recognition memory, and dendritic spine density in the hippocampus and medial prefrontal cortex, areas critical for memory, across the lifespan in female rodents. The present paper reviews the literature on dendritic spine plasticity in mediating both short and long term memory, as well as the decreased memory that occurs with aging and Alzheimer's disease. It also addresses the role of acute and chronic estrogen treatments in these processes.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.