ArticlePLoS neglected tropical diseases2015
Impact of Anti-Retroviral Treatment and Cotrimoxazole Prophylaxis on Helminth Infections in HIV-Infected Patients in Lambaréné, Gabon.
Article in PLoS neglected tropical diseases, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 2 of them syntheses that pooled it.
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Who cites it
16 citing papers in PubMed, 2 syntheses or guidelines pooled it, 19 citations in OpenAlex.
- Strongyloidiasis in Africa: Systematic Review and Meta-Analysis on Prevalence, Diagnostic Methods, and Study Settings.BioMed research international · 2020Pooled it
- The extent, nature, and pathogenic consequences of helminth polyparasitism in humans: A meta-analysis.PLoS neglected tropical diseases · 2019Pooled it
- Prevalence, antibiotic susceptibility, and genomic analysis ofFrontiers in microbiology · 2024Article
- Very low prevalence of Mansonella perstans-specific cell-free DNA in serum samples of Ghanaian HIV patients.European journal of microbiology & immunology · 2023Article
- Predictors of intestinal parasite infection among HIV patients on antiretroviral therapy in Jos, Plateau State, Nigeria, 2016: a cross-sectional survey.The Pan African medical journal · 2021Article
- Prevalence and Intensity ofResearch and reports in tropical medicine · 2021Article
- Prevalence and associated factors of intestinal parasite infection by HIV infection status among asymptomatic adults in rural Gabon.African health sciences · 2020Article
- Effect of Stopping Cotrimoxazole Preventive Therapy on Microbial Translocation and Inflammatory Markers Among Human Immunodeficiency Virus-Infected Ugandan Adults on Antiretroviral Therapy: The COSTOP Trial Immunology Substudy.The Journal of infectious diseases · 2020Article
- Tissue Parasites in HIV Infection.Current infectious disease reports · 2019Review
- RE: Intestinal Parasitic Infections in Human Immunodeficiency Virus-Infected and Noninfected Persons in a High Human Immunodeficiency Virus Prevalence Region of Cameroon.The American journal of tropical medicine and hygiene · 2018Article
- Prevalence of enteric parasitic infections among people living with HIV in Abeokuta, Nigeria.The Pan African medical journal · 2018Article
- Tropical Parasitic Infections in Individuals Infected with HIV.Current tropical medicine reports · 2017Article
- Article
- Prevalence and clinical relevance of helminth co-infections among tuberculosis patients in urban Tanzania.PLoS neglected tropical diseases · 2017Article
- Prevalence of Intestinal Parasites Among HIV Infected and HIV Uninfected Patients Treated at the 1° De Maio Health Centre in Maputo, Mozambique.EC microbiology · 2017Article
- Molecular Epidemiology of Blood-Borne Human Parasites in a Loa loa-, Mansonella perstans-, and Plasmodium falciparum-Endemic Region of Cameroon.The American journal of tropical medicine and hygiene · 2016Article
Corrections and comments
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Authors and funding
9 authors at 5 institutions in 6 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundFoci of the HIV epidemic and helminthic infections largely overlap geographically. Treatment options for helminth infections are limited, and there is a paucity of drug-development research in this area. Limited evidence suggests that antiretroviral therapy (ART) reduces prevalence of helminth infections in HIV-infected individuals. We investigated whether ART exposure and cotrimoxazole preventive therapy (CTX-P) is associated with a reduced prevalence of helminth infections. METHODOLOGY AND PRINCIPAL
findingsThis cross-sectional study was conducted at a primary HIV-clinic in Lambaréné, Gabon. HIV-infected adults who were ART-naïve or exposed to ART for at least 3 months submitted one blood sample and stool and urine samples on 3 consecutive days. Outcome was helminth infection with intestinal helminths, Schistosoma haematobium, Loa loa or Mansonella perstans. Multivariable logistic regression was used to assess associations between ART or CTX-P and helminth infection. In total, 408 patients were enrolled. Helminth infection was common (77/252 [30.5%]). Filarial infections were most prevalent (55/310 [17.7%]), followed by infection with intestinal helminths (35/296 [11.8%]) and S. haematobium (19/323 [5.9%]). Patients on CTX-P had a reduced risk of Loa loa microfilaremia (adjusted odds ratio (aOR) 0.47, 95% CI 0.23-0.97, P = 0.04), also in the subgroup of patients on ART (aOR 0.36, 95% CI 0.13-0.96, P = 0.04). There was no effect of ART exposure on helminth infection prevalence. CONCLUSIONS/SIGNIFICANCE: CTX-P use was associated with a decreased risk of Loa loa infection, suggesting an anthelminthic effect of antifolate drugs. No relation between ART use and helminth infections was established.
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