ArticleInternational journal of molecular sciences2015
Polymorphisms of the Ovine BMPR-IB, BMP-15 and FSHR and Their Associations with Litter Size in Two Chinese Indigenous Sheep Breeds.
Article in International journal of molecular sciences, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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26 citing papers in PubMed, 54 citations in OpenAlex.
- LncRNA and mRNA expression characteristics and bioinformatics analysis of exosomes from sheep ovaries with different reproductive capacities.Scientific data · 2026Article
- Effect ofAnimals : an open access journal from MDPI · 2025Article
- Genetic and Epigenetic Adaptation Mechanisms of Sheep Under Multi-Environmental Stress Environment.International journal of molecular sciences · 2025Review
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- Genetic Diversity, Selection Signatures, and Genome-Wide Association Study Identify Candidate Genes Related to Litter Size in Hu Sheep.International journal of molecular sciences · 2024Article
- Uncovering the genetic diversity and adaptability of Butuo Black Sheep through whole-genome re-sequencing.PloS one · 2024Article
- Characterization of polymorphisms in the follicle-stimulating hormone receptor and insulin-like growth factor-1 genes and their association with fertility traits in Jawa-Brebes cows.Veterinary world · 2023Article
- Pregnancy Toxemia in Ewes: A Review of Molecular Metabolic Mechanisms and Management Strategies.Metabolites · 2023Review
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- Are Copy Number Variations within theAnimals : an open access journal from MDPI · 2022Article
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- An ancient positively selected BMPRIB missense variant increases litter size of Mongolian sheep populations following latitudinal gradient.Molecular genetics and genomics : MGG · 2022Article
- Integrative Genome-Wide DNA Methylome and Transcriptome Analysis of Ovaries from Hu Sheep with High and Low Prolific.Frontiers in cell and developmental biology · 2022Article
- Detection of Novel Variations Related to Litter Size inAnimals : an open access journal from MDPI · 2021Article
- Polymorphism Detection ofAnimals : an open access journal from MDPI · 2021Article
- Effects ofFrontiers in veterinary science · 2021Article
- Comparison of expression patterns of six canonical clock genes of follicular phase and luteal phase in Small-tailed Han sheep.Archives animal breeding · 2021Article
- Luzhong mutton sheep: inbreeding and selection signatures.Journal of animal science and technology · 2020Article
- Molecular Characterization and Expression Profiles of the OvineAnimals : an open access journal from MDPI · 2020Article
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Authors and funding
10 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The Small Tailed Han sheep and Hu sheep are two prolific local sheep in China. In this study, the polymorphisms of BMPR-IB (Bone morphogenetic protein receptor IB), BMP-15 (Bone morphogenetic protein 15) and FSHR (follicle stimulating hormone receptor) were investigated to check whether they are associated with litter size in Small Tailed Han sheep and Hu sheep. Consequently, three polymorphisms, FecB mutation in BMPR-IB (c.746A>G), FecG mutation in BMP-15 (c.718C>T) and the mutation (g. 47C>T) in FSHR were found in the above two sheep breeds with a total number of 1630 individuals. The single marker association analysis showed that the three mutations were significantly associated with litter size. The ewes with genotype FecBB/FecBB and FecBB/FecB+ had 0.78 and 0.58 more lambs (p < 0.01) than those with genotype FecB+/FecB+, respectively. The heterozygous Han and Hu ewes with FecXG/FecX+ genotype showed 0.30 (p = 0.05) more lambs than those with the FecX+/FecX+ genotype. For FSHR gene, the ewes with genotype CC had 0.52 (p < 0.01) and 0.75 (p < 0.01) more lambs than those with genotypes TC and TT, respectively. Combined effect analyses indicated an extremely significant interaction (p < 0.01) between the random combinations of BMPR-IB, BMP-15 and FSHR genes on litter size. In addition, the Han and Hu ewes with BB/G+/CC genotype harbor the highest litter size among ewes analyzed in current study. In conclusion, BMPR-IB, BMP-15 and FSHR polymorphisms could be used as genetic markers in multi-gene pyramiding for improving litter size in sheep husbandry.
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