ArticleInternational journal of molecular sciences2015
Immunohistochemical analysis of paraoxonases and chemokines in arteries of patients with peripheral artery disease.
Article in International journal of molecular sciences, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 26 citations in OpenAlex.
- Blood Vessel Detection Algorithm for Tissue Engineering and Quantitative Histology.Annals of biomedical engineering · 2022Article
- Endothelial cell dysfunction: Implications for the pathogenesis of peripheral artery disease.Frontiers in cardiovascular medicine · 2022Review
- Endothelial cell-derived pro-fibrotic factors increase TGF-β1 expression by smooth muscle cells in response to cycles of hypoxia-hyperoxia.Biochimica et biophysica acta. Molecular basis of disease · 2022Article
- The Relevance of Noncoding DNA Variations of Paraoxonase Gene Cluster in Atherosclerosis-Related Diseases.International journal of molecular sciences · 2021Review
- TLR7/8 in the Pathogenesis of Parkinson's Disease.International journal of molecular sciences · 2020Article
- Article
- Oxidative Stress in Peripheral Arterial Disease (PAD) Mechanism and Biomarkers.Antioxidants (Basel, Switzerland) · 2019Review
- Sodium Butyrate Exerts Neuroprotective Effects in Spinal Cord Injury.Molecular neurobiology · 2019Article
- 2-Pentadecyl-2-Oxazoline Reduces Neuroinflammatory Environment in the MPTP Model of Parkinson Disease.Molecular neurobiology · 2018Article
- Trace Elements and Paraoxonase-1 Activity in Lower Extremity Artery Disease.Biological trace element research · 2018Article
- Treatment With a Flavonoid-Rich Fraction of Bergamot Juice Improved Lipopolysaccharide-Induced Periodontitis in Rats.Frontiers in pharmacology · 2018Article
- Plasma Energy-Balance Metabolites Discriminate Asymptomatic Patients with Peripheral Artery Disease.Mediators of inflammation · 2018Article
- Crossroads between peripheral atherosclerosis, western-type diet and skeletal muscle pathophysiology: emphasis on apolipoprotein E deficiency and peripheral arterial disease.Journal of biomedical science · 2017Review
- Galectin-3 in Peripheral Artery Disease. Relationships with Markers of Oxidative Stress and Inflammation.International journal of molecular sciences · 2017Article
Corrections and comments
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Authors and funding
11 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Oxidative damage to lipids and lipoproteins is implicated in the development of atherosclerotic vascular diseases, including peripheral artery disease (PAD). The paraoxonases (PON) are a group of antioxidant enzymes, termed PON1, PON2, and PON3 that protect lipoproteins and cells from peroxidation and, as such, may be involved in protection against the atherosclerosis process. PON1 inhibits the production of chemokine (C-C motif) ligand 2 (CCL2) in endothelial cells incubated with oxidized lipoproteins. PON1 and CCL2 are ubiquitously distributed in tissues, and this suggests a joint localization and combined systemic effect. The aim of the present study has been to analyze the quantitative immunohistochemical localization of PON1, PON3, CCL2 and CCL2 receptors in a series of patients with severe PAD. Portions of femoral and/or popliteal arteries from 66 patients with PAD were obtained during surgical procedures for infra-inguinal limb revascularization. We used eight normal arteries from donors as controls. PON1 and PON3, CCL2 and the chemokine-binding protein 2, and Duffy antigen/chemokine receptor, were increased in PAD patients. There were no significant changes in C-C chemokine receptor type 2. Our findings suggest that paraoxonases and chemokines play an important role in the development and progression of atherosclerosis in peripheral artery disease.
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