Evidence map›Paper›PMID 25993187›Full record

ReviewAmerican Society of Clinical Oncology educational book. American Society of Clinical Oncology. Annual Meeting2015

Evolving immunotherapy strategies in urothelial cancer.

Sam J Brancato, Keidren Lewi, Piyush K Agarwal

Abstract readReview
In one paragraph

Review in American Society of Clinical Oncology educational book. American Society of Clinical Oncology. Annual Meeting, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Sam J BrancatoFrom the Urologic Oncology Branch, National Cancer Institute at the National Institutes of Health, Bethesda, MD.
Keidren LewiFrom the Urologic Oncology Branch, National Cancer Institute at the National Institutes of Health, Bethesda, MD.
Piyush K AgarwalFrom the Urologic Oncology Branch, National Cancer Institute at the National Institutes of Health, Bethesda, MD.

Funding

Intramural NIH HHS Z99 CA999999
6 · The paper itself

Abstract

The treatment of nonmuscle-invasive urothelial carcinoma with bacillus Calmette-Guérin (BCG) represents the importance of immunotherapy in the treatment of cancer. Despite its clinical efficacy, up to 30% of patients will ultimately experience progression to muscle-invasive disease. This, along with an improved understanding of the biologic pathways involved, has led to efforts to improve, enhance, or alter the immune response in the treatment of urothelial carcinoma. A number of novel therapeutic approaches currently are being pursued, including recombinant BCG to induce T helper type 1 (Th1) immune responses, nonlive Mycobacterium agents, targeted agents toward cancer-associated antigens, immune-modulating vaccines, and adoptive T-cell therapies. Here, we review the current and future immunotherapy treatment options for patients with urothelial cancer.

Indexed as

AnimalsAntibodies, MonoclonalBCG VaccineCytokinesHumansImmunotherapyUrinary Bladder NeoplasmsAntibodies, MonoclonalBCG VaccineCytokines

Identifiers

PMID25993187
PMCPMC4903167

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.