Evidence map›Paper›PMID 25993177›Full record

ReviewAmerican Society of Clinical Oncology educational book. American Society of Clinical Oncology. Annual Meeting2015

Making sense of current and emerging therapies in pancreatic cancer: balancing benefit and value.

Daniel H Ahn, Andrew H Ko, Neal J Meropol, Tanios S Bekaii-Saab

Abstract readReview
In one paragraph

Review in American Society of Clinical Oncology educational book. American Society of Clinical Oncology. Annual Meeting, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Daniel H AhnFrom the The Ohio State University Wexner Medical Center, Columbus, OH; UCSF Helen Diller Comprehensive Cancer Center, San Francisco, CA; University Hospitals Seidman Cancer Center, Case Comprehensive Cancer Center, Case Western University, Cleveland, OH.
Andrew H KoFrom the The Ohio State University Wexner Medical Center, Columbus, OH; UCSF Helen Diller Comprehensive Cancer Center, San Francisco, CA; University Hospitals Seidman Cancer Center, Case Comprehensive Cancer Center, Case Western University, Cleveland, OH.
Neal J MeropolFrom the The Ohio State University Wexner Medical Center, Columbus, OH; UCSF Helen Diller Comprehensive Cancer Center, San Francisco, CA; University Hospitals Seidman Cancer Center, Case Comprehensive Cancer Center, Case Western University, Cleveland, OH.
Tanios S Bekaii-SaabFrom the The Ohio State University Wexner Medical Center, Columbus, OH; UCSF Helen Diller Comprehensive Cancer Center, San Francisco, CA; University Hospitals Seidman Cancer Center, Case Comprehensive Cancer Center, Case Western University, Cleveland, OH.

Funding

Training Hematology and Oncology Fellows in Clinical ResearchT32CA165998 · NCI · OHIO STATE UNIVERSITY · PI CLINTON, STEVEN K, GARZON, RAMIRO · 2012 to 2016
$944k
NCI NIH HHS T32 CA165998
6 · The paper itself

Abstract

Pancreatic cancer remains the fourth leading cause of cancer deaths in the United States with a dismal prognosis and a 5-year survival of less than 5% across all stages.(1) In 2014, there were approximately 46,420 new cases of pancreatic cancer with only 9% of patients having localized disease.(2) Given that the vast majority of patients present with advanced disease, much of the focus for drug development has been in the metastatic setting, which is evident with the advent of two combination chemotherapy regimens for this indication. Although conventional cytotoxic chemotherapy remains the standard of care, an ongoing search for novel therapeutic approaches continues. We will highlight several new approaches here, with a particular emphasis on immunotherapeutic strategies. We will also introduce concepts regarding the potential economic effects associated with the development and implementation of new treatments in pancreatic cancer.

Indexed as

Antineoplastic Combined Chemotherapy ProtocolsHumansPancreatic NeoplasmsRandomized Controlled Trials as Topic

Identifiers

PMID25993177
PMCPMC4964785

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.