Evidence map›Paper›PMID 25993082›Full record

ReviewEinstein (Sao Paulo, Brazil)

Liver transplantation: history, outcomes and perspectives.

Roberto Ferreira Meirelles Júnior, Paolo Salvalaggio, Marcelo Bruno de Rezende, Andréia Silva Evangelista, Bianca Della Guardia, Celso Eduardo Lourenço Matielo, Douglas Bastos Neves, Fernando Luis Pandullo, Guilherme Eduardo Gonçalves Felga, Jefferson André da Silva Alves and 8 more

Open access · diamondAbstract readHistorical ArticleReview
In one paragraph

Review in Einstein (Sao Paulo, Brazil). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 107 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
107citing papers in PubMed, 1 pooled it
7.4field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

107 citing papers in PubMed, 1 synthesis or guideline pooled it, 252 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Trial
  4. Review
  5. The Role of Gut Microbiota in Liver Regeneration After Partial Hepatectomy: New Evidence From Animal and Human Studies.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026
    Review
  6. Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Experimental model of small-for-size syndrome in pigs.Arquivos brasileiros de cirurgia digestiva : ABCD = Brazilian archives of digestive surgery · 2026
    Article
  14. Review
  15. Article
  16. Article
  17. Article
  18. Article
  19. cPLACytotechnology · 2025
    Article
  20. Review

47 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 2 institutions in 1 country.

Roberto Ferreira Meirelles JúniorHospital Israelita Albert Einstein, São Paulo, SP, Brazil.
Paolo SalvalaggioHospital Israelita Albert Einstein, São Paulo, SP, Brazil.
Marcelo Bruno de RezendeHospital Santa Marcelina, São Paulo, SP, Brazil.
Andréia Silva EvangelistaHospital Israelita Albert Einstein, São Paulo, SP, Brazil.
Bianca Della GuardiaHospital Israelita Albert Einstein, São Paulo, SP, Brazil.
Celso Eduardo Lourenço MatieloHospital Israelita Albert Einstein, São Paulo, SP, Brazil.
Douglas Bastos NevesHospital Israelita Albert Einstein, São Paulo, SP, Brazil.
Fernando Luis PandulloHospital Israelita Albert Einstein, São Paulo, SP, Brazil.
Guilherme Eduardo Gonçalves FelgaHospital Israelita Albert Einstein, São Paulo, SP, Brazil.
Jefferson André da Silva AlvesHospital Israelita Albert Einstein, São Paulo, SP, Brazil.
Lilian Amorim CurveloHospital Israelita Albert Einstein, São Paulo, SP, Brazil.
Luiz Gustavo Guedes DiazHospital Israelita Albert Einstein, São Paulo, SP, Brazil.
Marcela Balbo RusiHospital Israelita Albert Einstein, São Paulo, SP, Brazil.
Marcelo de Melo ViveirosHospital Santa Marcelina, São Paulo, SP, Brazil.
Marcio Dias de AlmeidaHospital Israelita Albert Einstein, São Paulo, SP, Brazil.
Pamella Tung PedrosoHospital Israelita Albert Einstein, São Paulo, SP, Brazil.
Rodrigo Andrey RoccoHospital Israelita Albert Einstein, São Paulo, SP, Brazil.
Sérgio Paiva Meira FilhoHospital Israelita Albert Einstein, São Paulo, SP, Brazil.
Hospital Israelita Albert Einstein · BRHospital Santa Marcelina · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In 1958 Francis Moore described the orthotopic liver transplantation technique in dogs. In 1963, Starzl et al. performed the first liver transplantation. In the first five liver transplantations no patient survived more than 23 days. In 1967, stimulated by Calne who used antilymphocytic serum, Starzl began a successful series of liver transplantation. Until 1977, 200 liver transplantations were performed in the world. In that period, technical problems were overcome. Roy Calne, in 1979, used the first time cyclosporine in two patients who had undergone liver transplantation. In 1989, Starzl et al. reported a series of 1,179 consecutives patients who underwent liver transplantation and reported a survival rate between one and five years of 73% and 64%, respectively. Finally, in 1990, Starzl et al. reported successful use of tacrolimus in patents undergoing liver transplantation and who had rejection despite receiving conventional immunosuppressive treatment. Liver Transplantation Program was initiated at Hospital Israelita Albert Einstein in 1990 and so far over 1,400 transplants have been done. In 2013, 102 deceased donors liver transplantations were performed. The main indications for transplantation were hepatocellular carcinoma (38%), hepatitis C virus (33.3%) and alcohol liver cirrhosis (19.6%). Of these, 36% of patients who underwent transplantation showed biological MELD score > 30. Patient and graft survival in the first year was, 82.4% and 74.8%, respectively. A major challenge in liver transplantation field is the insufficient number of donors compared with the growing demand of transplant candidates. Thus, we emphasize that appropriated donor/receptor selection, allocation and organ preservation topics should contribute to improve the number and outcomes in liver transplantation.

Indexed as

Liver TransplantationAnimalsBrazilDogsGraft RejectionGraft SurvivalHistory, 20th CenturyHistory, 21st CenturyHumansKaplan-Meier EstimateTreatment Outcome

Identifiers

PMID25993082
PMCPMC4977591
OpenAlexW1665091962

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.