SynthesisPloS one2015
Human papillomavirus infection and fertility alteration: a systematic review.
Synthesis in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
45 citing papers in PubMed, 3 syntheses or guidelines pooled it, 116 citations in OpenAlex.
- The Effect of Human Papillomavirus on Sperm Parameters: An Umbrella Review and Meta-analysis.International journal of fertility & sterility · 2026Pooled it
- Impact of human papillomavirus infection in semen on sperm progressive motility in infertile men: a systematic review and meta-analysis.Reproductive biology and endocrinology : RB&E · 2020Pooled it
- The risk of human papillomavirus infection for male fertility abnormality: a meta-analysis.Asian journal of andrologyPooled it
- Human papillomavirus vaccinations' association to childbirth rates.Human vaccines & immunotherapeutics · 2026Article
- Protective Effects of Lactobacillus-Derived Probiotics and Postbiotics on Renal and Reproductive Function in Escherichia coli-Infected Rats.Veterinary medicine and science · 2026Article
- Homo sapiens, industrialisation and the environmental mismatch hypothesis.Biological reviews of the Cambridge Philosophical Society · 2026Review
- Beyond infection status: a cross-sectional study of socioeconomic disparities, infection dynamics, and psychosocial burden among women with HPV in Luzhou, China.BMC women's health · 2025Article
- HPV Prevalence and Genotype Distribution Among Infertile and Fertile Women of Turkish Nationality and Association with Cytology and Vaccination Status.Biomedicines · 2025Article
- Human Papillomavirus (HPV) and Infertility: A Cross-Sectional Study Exploring Its Prevalence and Effects in Iranian Couples.Health science reports · 2025Article
- Semen HPV and IVF: insights from infection prevalence to embryologic outcomes.Journal of assisted reproduction and genetics · 2025Article
- Testicular immunity.Molecular aspects of medicine · 2024Review
- The Impact of Human Papillomavirus Infections on Recurrent Pregnancy Loss: A Review of the Literature.Diseases (Basel, Switzerland) · 2024Article
- Cervical intraepithelial neoplasia and fecundability: a prospective cohort study.Human reproduction (Oxford, England) · 2024Article
- Update on known and emergent viruses affecting human male genital tract and fertility.Basic and clinical andrology · 2024Review
- Effect of environmental factors on seminal microbiome and impact on sperm quality.Frontiers in endocrinology · 2024Review
- Infectious diseases may have arrested the southward advance of microblades in Upper Palaeolithic East Asia.Proceedings. Biological sciences · 2023Article
- Inequities in Screening and HPV Vaccination Programs and Their Impact on Cervical Cancer Statistics in Romania.Diagnostics (Basel, Switzerland) · 2023Article
- The Immune Response Generated against HPV Infection in Men and Its Implications in the Diagnosis of Cancer.Microorganisms · 2023Review
- Are sexually transmitted infections associated with male infertility? A systematic review and in-depth evaluation of the evidence and mechanisms of action of 11 pathogens.Arab journal of urology · 2023Review
- HPV and vaginal microecological disorders in infertile women: a cross-sectional study in the Chinese population.Virology journal · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundHPV is the most prevalent sexually transmitted infection and its effect in cancer induction is well documented. HPV infections are mostly asymptomatic, but it is unclear whether HPV infections can result in alterations of reproductive health.
objectiveTo determine the relationship between human papillomavirus infections and reproductive health in both men and women.
methodsA systematic literature review was performed in PubMed and ScienceDirect data bases from January 1994 through August 2014.
resultsHPV infections are shown to be significantly associated to many adverse effects in the reproductive function. These adverse effects were reported in different levels from cells production to pregnancy and may be related to the infecting genotype.
conclusionsIt appears from this study that HPV detection and genotyping could be of great value in infertility diagnosis at least in idiopathic infertility cases. Like for the risk of carcinogenesis, another classification of HPV regarding the risk of fertility alteration may be considered after deep investigations.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.