Evidence map›Paper›PMID 25992781›Full record

ArticlePLoS medicine2015

An unsupported preference for intravenous antibiotics.

Ho Kwong Li, Ambrose Agweyu, Mike English, Philip Bejon

Registry-linked trialAbstract read
In one paragraph

Article in PLoS medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04471246 (High-dose Cephalexin for Cellulitis), which is not on this map. Cited by 37 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04471246 phase4completednot on this mapstarted 2021, after this paper: background citation

High-dose Cephalexin for Cellulitis: A Pilot Randomized Controlled Trial

TypeinterventionalSponsorOttawa Hospital Research InstituteRan2021 to 2022Enrolled69ConditionsCellulitisArmsCephalexin, Cephalexin + placebo
3 · Its place in the literature

Who cites it

37 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Amikacin Liposome Inhalation Suspension forAnnals of the American Thoracic Society · 2021
    Trial
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  7. Review
  8. Review
  9. Article
  10. Article
  11. Review
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  13. Article
  14. Oral quinolones versus intravenous β-lactam for the treatment of acute focal bacterial nephritis: a retrospective cohort study.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2024
    Article
  15. Article
  16. Article
  17. Review
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Ho Kwong LiBone Infection Unit, Nuffield Orthopaedic Centre, Oxford University Hospitals, Oxford, United Kingdom.
Ambrose AgweyuKenya Medical Research Institute Wellcome Trust Research Programme, Nairobi, Kenya.
Mike EnglishKenya Medical Research Institute Wellcome Trust Research Programme, Nairobi, Kenya; Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom.
Philip BejonBone Infection Unit, Nuffield Orthopaedic Centre, Oxford University Hospitals, Oxford, United Kingdom; Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom; Kenya Medical Research Institute Wellcome Trust Research Programme, Kilifi, Kenya.

Funding

Department of Health 11/36/29Medical Research CouncilWellcome Trust 076827Wellcome Trust 084538Wellcome Trust 092654Wellcome Trust 097170
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Administration, OralAnti-Bacterial AgentsEndocarditisHumansInfusions, IntravenousOsteomyelitisPyelonephritisRandomized Controlled Trials as TopicAnti-Bacterial Agents

Identifiers

PMID25992781
PMCPMC4437896

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.