ArticleBiophysical journal2015
Annealed random copolymer model of the B-Z transition in DNA: torsional responses.
Article in Biophysical journal, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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2 citing papers in PubMed, 5 citations in OpenAlex.
- Interplay of chromatin organization and mechanics of the cell nucleus.Biophysical journal · 2024Article
- Free energy measurements by the generalized fluctuation theorems: Theory and numerical study of a model filament.The European physical journal. E, Soft matter · 2020Article
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5 authors at 3 institutions in 2 countries.
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Abstract
Both in vivo and in vitro, specific sequences in double-stranded DNA can adopt the left-handed Z-form when underwound. Recently, the B-Z transition of DNA has been studied in detail in magnetic tweezers experiments by several groups. We present a theoretical description of this transition, based on an annealed random copolymer model. The transition of a switchable sequence is discussed as a function of energetic and geometric parameters of the B- and Z-forms, of the applied boundary conditions, and of the characteristics of the B-Z interface. We address a possible torsional softening upon the B-Z transition. The model can be also applied to other biofilaments with annealed torsional/flexural degrees of freedom.
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