ArticleFrontiers in psychology2015
Neuroanatomical substrates for the volitional regulation of heart rate.
Article in Frontiers in psychology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 27 citations in OpenAlex.
- Mapping the "Depression Switch" During Intraoperative Testing of Subcallosal Cingulate Deep Brain Stimulation.JAMA neurology · 2015Trial
- Central autonomic network-heart interplay in anorexia nervosa. A cross-spectral dynamic causal modeling study.NeuroImage. Clinical · 2026Article
- Aberrant recruitment of the striatum and insula is associated with recalling and suppressing fatigue- and anger-related memories in people with chronic fatigue syndrome/myalgic encephalomyelitis.Brain communications · 2026Article
- Examining Insula-Default Mode Network Functional Connectivity and Its Relationship with Heart Rate Variability.Brain sciences · 2025Article
- Nocturnal swallowing augments arousal intensity and arousal tachycardia.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Inhibition of food craving is a metabolically active process in the brain in obese men.International journal of obesity (2005) · 2020Article
- Volitional Control of Piloerection: Objective Evidence and Its Potential Utility in Neuroscience Research.Frontiers in neuroscience · 2020Article
- The Mammalian Diving Response: Inroads to Its Neural Control.Frontiers in neuroscience · 2020Review
- Social anxiety, posterior insula activation, and autonomic response during self-initiated action in a Cyberball game.Journal of affective disorders · 2019Article
- Promoting Psychological Well-Being Through an Evidence-Based Mindfulness Training Program.Frontiers in human neuroscience · 2019Article
- Working With the Predictable Life of Patients: The Importance of "Mentalizing Interoception" to Meaningful Change in Psychotherapy.Frontiers in psychology · 2019Article
- The verbal nature of worry in generalized anxiety: Insights from the brain.NeuroImage. Clinical · 2018Article
- How Human Amygdala and Bed Nucleus of the Stria Terminalis May Drive Distinct Defensive Responses.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
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Authors and funding
8 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The control of physiological arousal can assist in the regulation of emotional state. A subset cortical and subcortical brain regions are implicated in autonomic control of bodily arousal during emotional behaviors. Here, we combined human functional neuroimaging with autonomic monitoring to identify neural mechanisms that support the volitional regulation of heart rate, a process that may be assisted by visual feedback. During functional magnetic resonance imaging (fMRI), 15 healthy adults performed an experimental task in which they were prompted voluntarily to increase or decrease cardiovascular arousal (heart rate) during true, false, or absent visual feedback. Participants achieved appropriate changes in heart rate, without significant modulation of respiratory rate, and were overall not influenced by the presence of visual feedback. Increased activity in right amygdala, striatum and brainstem occurred when participants attempted to increase heart rate. In contrast, activation of ventrolateral prefrontal and parietal cortices occurred when attempting to decrease heart rate. Biofeedback enhanced activity within occipito-temporal cortices, but there was no significant interaction with task conditions. Activity in regions including pregenual anterior cingulate and ventral striatum reflected the magnitude of successful task performance, which was negatively related to subclinical anxiety symptoms. Measured changes in respiration correlated with posterior insula activation and heart rate, at a more lenient threshold, change correlated with insula, caudate, and midbrain activity. Our findings highlight a set of brain regions, notably ventrolateral prefrontal cortex, supporting volitional control of cardiovascular arousal. These data are relevant to understanding neural substrates supporting interaction between intentional and interoceptive states related to anxiety, with implications for biofeedback interventions, e.g., real-time fMRI, that target emotional regulation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.