Evidence map›Paper›PMID 25992621›Full record

SynthesisPloS one2015

Epidemiology of pediatric functional abdominal pain disorders: a meta-analysis.

Judith J Korterink, Kay Diederen, Marc A Benninga, Merit M Tabbers

4 registry-linked trialsOpen access · goldAbstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 4 registered trials, which are not on this map. Cited by 196 papers, 13 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
196citing papers in PubMed, 13 pooled it
65.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02880332 nacompletednot on this mapstarted 2017, after this paper: background citation

Endogenous Pain Processing and Effectiveness of Pain Neuroscience Education in Children With Functional Abdominal Pain and Irritable Bowel Syndrome

TypeinterventionalSponsorVrije Universiteit BrusselRan2017 to 2018Enrolled75ConditionsAbdominal Pain, Irritable Bowel SyndromeArmsUsual care, Pain Neuroscience education, Extra care
NCT03162835 completednot on this mapstarted 2017, after this paper: background citation

Development and Clinimetric Properties of the Dutch Pediatric Neurophysiology of Pain Questionnaire in Healthy Children

TypeobservationalSponsorVrije Universiteit BrusselRan2017 to 2018Enrolled111ConditionsSurveys and Questionnaires, Child, Pain, KnowledgeArmsPain Neuroscience Education
NCT03164343 nacompletednot on this mapstarted 2017, after this paper: background citation

Pain Neuroscience Education in Healthy Children: A Pilot Study

TypeinterventionalSponsorVrije Universiteit BrusselRan2017 to 2018Enrolled27ConditionsChild, PainArmsPain Neuroscience Education for children
NCT06268964 phase1 / phase2recruitingnot on this mapstarted 2024, after this paper: background citation

Comparative Effect of Trimebutine and Probiotics on Functional Abdominal Pain Disorders (FAPD) in Children: Randomized Clinical Trial (RCT)

TypeinterventionalSponsorUniversidad de ColimaRan2024 to 2025Enrolled82ConditionsFunctional Abdominal Pain Syndrome, Functional Gastrointestinal Disorders, Irritable Bowel Syndrome Variant of ChildhoodArmsTrimebutine, Lactobacillus rhamnosus, Placebo
3 · Its place in the literature

Who cites it

196 citing papers in PubMed, 13 syntheses or guidelines pooled it, 469 citations in OpenAlex.

  1. Efficacy and Safety ofNutrients · 2026
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  13. Dietary interventions for recurrent abdominal pain in childhood.The Cochrane database of systematic reviews · 2017
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  15. Effectiveness of hypnotherapy for paediatric abdominal pain in primary care: a randomised controlled trial.The British journal of general practice : the journal of the Royal College of General Practitioners · 2026
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136 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Judith J KorterinkDepartment of Pediatric Gastroenterology and Nutrition, Emma's Children's Hospital Academic Medical Center, Amsterdam, The Netherlands.
Kay DiederenDepartment of Pediatric Gastroenterology and Nutrition, Emma's Children's Hospital Academic Medical Center, Amsterdam, The Netherlands.
Marc A BenningaDepartment of Pediatric Gastroenterology and Nutrition, Emma's Children's Hospital Academic Medical Center, Amsterdam, The Netherlands.
Merit M TabbersDepartment of Pediatric Gastroenterology and Nutrition, Emma's Children's Hospital Academic Medical Center, Amsterdam, The Netherlands.
Amsterdam UMC Location University of Amsterdam · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveWe aimed to review the literature regarding epidemiology of functional abdominal pain disorders in children and to assess its geographic, gender and age distribution including associated risk factors of developing functional abdominal pain.

methodsThe Cochrane Library, MEDLINE, EMBASE, CINAHL and PsychInfo databases were systematically searched up to February 2014. Study selection criteria included: (1) studies of birth cohort, school based or general population samples (2) containing data concerning epidemiology, prevalence or incidence (3) of children aged 4-18 years (4) suffering from functional abdominal pain. Quality of studies was rated by a self-made assessment tool. A random-effect meta-analysis model was used to estimate the prevalence of functional abdominal pain in childhood.

resultsA total of 58 articles, including 196,472 children were included. Worldwide pooled prevalence for functional abdominal pain disorders was 13.5% (95% CI 11.8-15.3), of which irritable bowel syndrome was reported most frequently (8.8%, 95% CI 6.2-11.9). The prevalence across studies ranged widely from 1.6% to 41.2%. Higher pooled prevalence rates were reported in South America (16.8%) and Asia (16.5%) compared to Europe (10.5%). And a higher pooled prevalence was reported when using the Rome III criteria (16.4%, 95% CI 13.5-19.4). Functional abdominal pain disorders are shown to occur significantly more in girls (15.9% vs. 11.5%, pooled OR 1.5) and is associated with the presence of anxiety and depressive disorders, stress and traumatic life events.

conclusionFunctional abdominal pain disorders are a common problem worldwide with irritable bowel syndrome as most encountered abdominal pain-related functional gastrointestinal disorder. Female gender, psychological disorders, stress and traumatic life events affect prevalence.

Indexed as

Abdominal PainChildGeographyHumansPrevalenceReproducibility of ResultsSurveys and Questionnaires

Identifiers

PMID25992621
PMCPMC4439136
OpenAlexW324818206

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.