ArticlePloS one2015
MiR-191 Regulates Primary Human Fibroblast Proliferation and Directly Targets Multiple Oncogenes.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed.
- Clinical utility of cell-free urine miR-93-5p, miR-191-5p, miR-31-5p for invasive urothelial carcinoma detection and immune signature-based subtyping.BMC urology · 2026Article
- miR-191 affects skeletal muscle differentiation by regulating Wwp1 in mouse myoblasts.PloS one · 2026Article
- Free circulating versus extracellular vesicle-associated microRNA expression in canine T-cell lymphoma.Frontiers in veterinary science · 2024Article
- The Role of microRNAs in Organismal and Skin Aging.International journal of molecular sciences · 2020Review
- Emerging insights into the biology of metastasis: A review article.Iranian journal of basic medical sciences · 2019Review
- PRC2 activates interferon-stimulated genes indirectly by repressing miRNAs in glioblastoma.PloS one · 2019Article
- MicroRNA-664-5p promotes myoblast proliferation and inhibits myoblast differentiation by targeting serum response factor andThe Journal of biological chemistry · 2018Article
- Identification and removal of sequencing artifacts produced by mispriming during reverse transcription in multiple RNA-seq technologies.RNA (New York, N.Y.) · 2018Article
- Clinical significance of microRNA-449a in hepatocellular carcinoma with microarray data mining together with initial bioinformatics analysis.Experimental and therapeutic medicine · 2018Article
- MicroRNA-191-5p exerts a tumor suppressive role in renal cell carcinoma.Experimental and therapeutic medicine · 2018Article
- An elevated expression of serum exosomal microRNA-191, - 21, -451a of pancreatic neoplasm is considered to be efficient diagnostic marker.BMC cancer · 2018Article
- The biology of Hepatocellular carcinoma: implications for genomic and immune therapies.Molecular cancer · 2017Review
- Identification of the miRNA-target gene regulatory network in intracranial aneurysm based on microarray expression data.Experimental and therapeutic medicine · 2017Article
- Expression and Clinical Pathological Significance of miR-200a in Concurrent Cholangiocarcinoma Associated with Hepatolithiasis.Medical science monitor : international medical journal of experimental and clinical research · 2015Article
- Tracking Distinct RNA Populations Using Efficient and Reversible Covalent Chemistry.Molecular cell · 2015Article
- miR-125b suppresses the proliferation of hepatocellular carcinoma cells by targeting Sirtuin7.International journal of clinical and experimental medicine · 2015Article
- Upregulation of PD-L1 predicts poor prognosis and is associated with miR-191-5p dysregulation in colon adenocarcinoma.International journal of immunopathology and pharmacologyArticle
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
miRNAs play a central role in numerous pathologies including multiple cancer types. miR-191 has predominantly been studied as an oncogene, but the role of miR-191 in the proliferation of primary cells is not well characterized, and the miR-191 targetome has not been experimentally profiled. Here we utilized RNA induced silencing complex immunoprecipitations as well as gene expression profiling to construct a genome wide miR-191 target profile. We show that miR-191 represses proliferation in primary human fibroblasts, identify multiple proto-oncogenes as novel miR-191 targets, including CDK9, NOTCH2, and RPS6KA3, and present evidence that miR-191 extensively mediates target expression through coding sequence (CDS) pairing. Our results provide a comprehensive genome wide miR-191 target profile, and demonstrate miR-191's regulation of primary human fibroblast proliferation.
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