ArticlePLoS biology2015
Applying the ARRIVE Guidelines to an In Vivo Database.
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Article in PLoS biology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 69 papers.
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69 citing papers in PubMed.
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9 more citing papers are in PubMed but not listed here.
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Authors and funding
30 authors.
Natasha A KarpMouse Informatics Group, Wellcome Trust Sanger Institute, Cambridge, United Kingdom.
Terry F MeehanSamples, Phenotypes and Ontologies, European Molecular Biology Laboratory-European Bioinformatics Institute, Cambridge, United Kingdom.
Hugh MorganMammalian Genetics Unit, Medical Research Council, Harwell, United Kingdom.
Jeremy C MasonSamples, Phenotypes and Ontologies, European Molecular Biology Laboratory-European Bioinformatics Institute, Cambridge, United Kingdom.
Andrew BlakeMammalian Genetics Unit, Medical Research Council, Harwell, United Kingdom.
Natalja KurbatovaSamples, Phenotypes and Ontologies, European Molecular Biology Laboratory-European Bioinformatics Institute, Cambridge, United Kingdom.
Damian SmedleyMouse Informatics Group, Wellcome Trust Sanger Institute, Cambridge, United Kingdom.
Julius JacobsenMouse Informatics Group, Wellcome Trust Sanger Institute, Cambridge, United Kingdom.
Richard F MottThe Wellcome Trust Centre for Human Genetics, Oxford University, Oxford, United Kingdom.
Vivek IyerCellular Genetics, Wellcome Trust Sanger Institute, Cambridge, United Kingdom.
Peter MatthewsCellular Genetics, Wellcome Trust Sanger Institute, Cambridge, United Kingdom.
David G MelvinMouse Informatics Group, Wellcome Trust Sanger Institute, Cambridge, United Kingdom.
Sara WellsMammalian Genetics Unit, Medical Research Council, Harwell, United Kingdom.
Ann M FlennikenToronto Centre for Phenogenomics, Mount Sinai Hospital, Toronto, Canada.
Hiroshi MasuyaBioResource Center, RIKEN, Tsukuba, Japan.
Shigeharu WakanaBioResource Center, RIKEN, Tsukuba, Japan.
Jacqueline K WhiteMouse Genetics Project, Wellcome Trust Sanger Institute, Cambridge, United Kingdom.
K C Kent LloydMouse Biology Program, University of California Davis, Davis, California, United States of America.
Corey L ReynoldsMolecular Physiology and Biophysics, Baylor College of Medicine, Houston, Texas, United States of America.
Richard PaylorMolecular and Human Genetics, Baylor College of Medicine, Houston, Texas, United States of America.
David B WestGenetics, Children's Hospital Oakland Research Institute, Oakland, California, United States of America.
Karen L SvensonGenetics, The Jackson Laboratory, Bar Habour, Maine, United States of America.
Elissa J CheslerGenetics, The Jackson Laboratory, Bar Habour, Maine, United States of America.
Martin Hrabě de AngelisGerman Mouse Clinic-Institute of Experimental Genetics, Helmholtz Zentrum München, Neuherberg, Germany; Experimental Genetics-Center of Life and Food, Technische Universität München, Freising-Weihenstephan, Germany.
Glauco P Tocchini-ValentiniMonterotondo Mouse Clinic, CNR Institute of Cell Biology and Neurobiology, Monterotondo, Scalo, Italy.
Tania SorgPHENOMIN, Centre National de la Recherche Scientifique, Illkirch, France; Institut Clinique de la Souris, Université de Strasbourg, Illkirch, France; Institut de Génétique et de Biologie Moléculaire et Cellulaire, Institut National de la Santé et de la Recherche Médicale U964, Illkirch, France.
Yann HeraultPHENOMIN, Centre National de la Recherche Scientifique, Illkirch, France; Institut Clinique de la Souris, Université de Strasbourg, Illkirch, France; Institut de Génétique et de Biologie Moléculaire et Cellulaire, Institut National de la Santé et de la Recherche Médicale U964, Illkirch, France.
Helen ParkinsonSamples, Phenotypes and Ontologies, European Molecular Biology Laboratory-European Bioinformatics Institute, Cambridge, United Kingdom.
Ann-Marie MallonMammalian Genetics Unit, Medical Research Council, Harwell, United Kingdom.
Steve D M BrownMammalian Genetics Unit, Medical Research Council, Harwell, United Kingdom.
Funding
Shared Resource ManagementP30CA034196 · NCI · JACKSON LABORATORY · PI William Carl Skarnes · 1985 to 2026
$61.9MUM1HG006348: Cas9 Genome Integrity Supplemental ProposalUM1HG006348 · NHGRI · BAYLOR COLLEGE OF MEDICINE · PI Jason D. Heaney, Chih-Wei Logan Hsu · 2016 to 2026
$47.5MKOMP2-Phase3 Production and Phenotyping by the DTCC Consortium TCP Transfer to UC DavisUM1OD023221 · OD · UNIVERSITY OF CALIFORNIA AT DAVIS · PI KC KENT LLOYD · 2016 to 2026
$45.7MUCD Mutant Mouse Regional Resource CenterU42OD012210 · OD · UNIVERSITY OF CALIFORNIA AT DAVIS · PI KC KENT LLOYD · 2012 to 2026
$29.2MKOMP Phase II Mouse Production and CryopreservationU42OD011175 · OD · UNIVERSITY OF CALIFORNIA AT DAVIS · PI LLOYD, KC KENT · 2012 to 2015
$18.9MCRSPR II Supplement: Consortium for the production and cryopreservation of knockout miceU42OD011174 · OD · BAYLOR COLLEGE OF MEDICINE · PI BEAUDET, ARTHUR L. · 2012 to 2015
$17.7MConsortium for Broad Based Disease Phenotyping of Knockout MiceU54HG006348 · NHGRI · BAYLOR COLLEGE OF MEDICINE · PI BEAUDET, ARTHUR L., PAYLOR, RICHARD E · 2011 to 2015
$17.0MKOMP Phase II Mouse PhenotypingU54HG006364 · NHGRI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI LLOYD, KC KENT · 2011 to 2015
$16.3MThe Jackson Laboratory KOMP2 Phenotyping CenterU54HG006332 · NHGRI · JACKSON LABORATORY · PI BRAUN, ROBERT E, SVENSON, KAREN L · 2011 to 2015
$12.8MMouse Phenotyping Informatics Infrastruture - MP12U54HG006370 · NHGRI · EUROPEAN MOLECULAR BIOLOGY LABORATORY · PI BROWN, STEVE, FLICEK, PAUL · 2011 to 2015
$11.4MMedical Research Council MC_U142684171Medical Research Council MC_U142684172Medical Research Council MC_UP_1502/3NCI NIH HHS P30 CA034196NHGRI NIH HHS U54 HG006332NHGRI NIH HHS U54-HG006332NHGRI NIH HHS U54 HG006348NHGRI NIH HHS U54-HG006348NHGRI NIH HHS U54 HG006364NHGRI NIH HHS U54 HG006364-01NHGRI NIH HHS U54 HG006370NHGRI NIH HHS U54 HG006370-01NHGRI NIH HHS UM1 HG006348NIH HHS U42 OD011174NIH HHS U42 OD011175NIH HHS U42 OD012210NIH HHS U42-OD11174NIH HHS UM1 OD023221Wellcome TrustWellcome Trust 083573/Z/07/ZWellcome Trust 090532/Z/09/ZWellcome Trust WT098051
Abstract
The Animal Research: Reporting of In Vivo Experiments (ARRIVE) guidelines were developed to address the lack of reproducibility in biomedical animal studies and improve the communication of research findings. While intended to guide the preparation of peer-reviewed manuscripts, the principles of transparent reporting are also fundamental for in vivo databases. Here, we describe the benefits and challenges of applying the guidelines for the International Mouse Phenotyping Consortium (IMPC), whose goal is to produce and phenotype 20,000 knockout mouse strains in a reproducible manner across ten research centres. In addition to ensuring the transparency and reproducibility of the IMPC, the solutions to the challenges of applying the ARRIVE guidelines in the context of IMPC will provide a resource to help guide similar initiatives in the future.
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Databases as TopicGuidelines as TopicPhenotypeAnimal ExperimentationAnimalsMice
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