Evidence map›Paper›PMID 25992591›Full record

ArticleOrganic letters2015

Facile Rh(III)-Catalyzed Synthesis of Fluorinated Pyridines.

Shuming Chen, Robert G Bergman, Jonathan A Ellman

Abstract read
In one paragraph

Article in Organic letters, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. DABCO- and DBU-promoted one-pot reaction ofBeilstein journal of organic chemistry · 2018
    Article
  3. RhChemical science · 2015
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Shuming Chen†Department of Chemistry, Yale University, New Haven, Connecticut 06520, United States.
Robert G Bergman‡Division of Chemical Sciences, Lawrence Berkeley National Laboratory, and Department of Chemistry, University of California-Berkeley, Berkeley, California 94720, United States.
Jonathan A Ellman†Department of Chemistry, Yale University, New Haven, Connecticut 06520, United States.

Funding

C-H Functionalization for the Synthesis of Amines and Nitrogen HeterocyclesR01GM069559 · NIGMS · YALE UNIVERSITY · PI ELLMAN, JONATHAN A · 2004 to 2017
$5.4M
NIGMS NIH HHS R01 GM069559NIGMS NIH HHS R01-GM069559
6 · The paper itself

Abstract

A Rh(III)-catalyzed C-H functionalization approach was developed for the preparation of multisubstituted 3-fluoropyridines from α-fluoro-α,β-unsaturated oximes and alkynes. Oximes substituted with aryl, heteroaryl, and alkyl β-substituents were effective coupling partners, as were symmetrical and unsymmetrical alkynes with aryl and alkyl substituents. The first examples of coupling α,β-unsaturated oximes with terminal alkynes was also demonstrated and proceeded with uniformly high regioselectivity to provide single 3-fluoropyridine regioisomers. Reactions were also conveniently set up in air on the benchtop.

Indexed as

CatalysisHalogenationHydrocarbons, FluorinatedMolecular StructureOrganoselenium CompoundsPyridinesRhodiumHydrocarbons, FluorinatedOrganoselenium CompoundsPyridinesRhodium

Identifiers

PMID25992591
PMCPMC4477688

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.