Observational studyThe American journal of the medical sciences2015
Procalcitonin is a marker of gram-negative bacteremia in patients with sepsis.
Observational study in The American journal of the medical sciences, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 2 of them syntheses that pooled it.
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Who cites it
26 citing papers in PubMed, 2 syntheses or guidelines pooled it, 87 citations in OpenAlex.
- Accuracy of procalcitonin for diagnosing sepsis in adult patients admitted to the emergency department: a systematic review and meta-analysis.Systematic reviews · 2024Pooled it
- Prognostic differences in sepsis caused by gram-negative bacteria and gram-positive bacteria: a systematic review and meta-analysis.Critical care (London, England) · 2023Pooled it
- Influence of pathogen and focus of infection on procalcitonin values in sepsis patients with bacteremia or candidemia.Critical care (London, England) · 2018Trial
- Understanding the microRNA signature associated with Reye's syndrome.Protoplasma · 2026Review
- Development and Validation of an Interpretable Machine Learning Model for Predicting Carbapenem-ResistantInfection and drug resistance · 2026Article
- Diagnostic biomarkers for late-onset sepsis in pediatric intensive care: a retrospective cohort study.BMC pediatrics · 2025Article
- Impact of the COVID-19 Pandemic on the Epidemiology of Bloodstream Infections in Hospitalized Patients-Experience from a 4th Military Clinical Hospital in Poland.Journal of clinical medicine · 2023Article
- One year experience ofAccess microbiology · 2023Article
- A study on biomarkers of sepsis and potential role of procalcitonin and ferritin marker in diagnosis, prognosis and treatment.Journal of family medicine and primary care · 2022Article
- Clinico-bacterial and prognostic factors in patients with suspected blood stream infection and elevated serum procalcitonin levels.Nagoya journal of medical science · 2022Article
- Label-free electrochemical biosensor for determination of procalcitonin based on graphene-wrapped Co nanoparticles encapsulated in carbon nanobrushes coupled with AuPtCu nanodendrites.Mikrochimica acta · 2022Article
- Clinical utility of procalcitonin in severe odontogenic maxillofacial infection.Maxillofacial plastic and reconstructive surgery · 2021Article
- CRP/albumin ratio: A promising marker of gram-negative bacteremia in late-onset neonatal sepsis.Turkish archives of pediatrics · 2021Article
- Combination of biomarker with clinical risk factors for prediction of severe acute kidney injury in critically ill patients.BMC nephrology · 2020Article
- Serum procalcitonin as a biomarker of bloodstream infection & focal bacterial infection in febrile patients.The Indian journal of medical research · 2020Article
- Procalcitonin in hemodialysis patients presenting with fever or chills to the emergency department.Internal and emergency medicine · 2020Article
- Ability of serum procalcitonin to distinguish focus of infection and pathogen types in patients with bloodstream infection.Annals of translational medicine · 2019Article
- Diagnostic Accuracy of Procalcitonin for Differentiating Bacteraemic Gram-Negative Sepsis from Gram-Positive Sepsis.Turkish journal of anaesthesiology and reanimation · 2018Article
- Procalcitonin Value Is an Early Prognostic Factor Related to Mortality in Admission to Pediatric Intensive Care Unit.Critical care research and practice · 2018Article
- Procalcitonin is a Poor Predictor of Non-Infectious Fever in the Neurocritical Care Unit.Neurocritical care · 2017Observational
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPrediction of the species of pathogen among patients with sepsis within hours would be helpful in accelerating proper treatment. As a potential method of shortening the time to identification, this study considered the usefulness of measuring procalcitonin (PCT) to predict blood culture (BC) results.
methodsThe authors retrospectively analyzed the data of patients with a diagnosis of sepsis in their hospital from December 2012 to December 2013. The authors analyzed all diagnostic episodes consisting of BC and PCT concentration. The diagnostic performance of PCT to predict gram-negative bacteremia was tested using a receiver operative characteristic curve. Logistic regression was constructed using the presence of gram-negative bacteria as the dependent variable.
resultsA total of 262 diagnostic episodes met the inclusion criteria. According to BC classifications, a significantly higher value of PCT was observed in bloodstream infections caused by gram-negative bacteria (26.7 ng/mL, 0.09-188.3) than that in bloodstream infections caused by gram-positive bacteria (0.84 ng/mL, 0.05-18.79) or Candida spp. (1.12 ng/mL, 0.07-49.68). A cutoff value of ≥ 3.39 ng/mL for PCT showed a sensitivity of 80%, a specificity of 71%, a positive predictive value of 35%, a negative predictive value of 91% and an area under the curve of 0.73 for gram-negative bacteremia identification by BC. Among the 122 diagnostic episodes with positive BC results, a cutoff value of ≥ 6.47 ng/mL for PCT yielded a sensitivity of 74%, a specificity of 81%, a positive predictive value of 82%, a negative predictive value of 75% and an area under the curve of 0.81 for gram-negative bacteremia identification.
conclusionsPCT may represent a useful tool for differentiating gram-positive from gram-negative bloodstream infection with a significantly higher PCT level indicating gram-negative bacteremia.
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