ArticleJournal of visualized experiments : JoVE2015
Systemic bacterial infection and immune defense phenotypes in Drosophila melanogaster.
Article in Journal of visualized experiments : JoVE, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
41 citing papers in PubMed, 68 citations in OpenAlex.
- Juvenile hormone signaling acts during development and post-mating to suppress antibacterial defenses in Drosophila melanogaster.Scientific reports · 2026Article
- Knockouts of Sulfur Metabolism Genes Induce Chronic Inflammation and Immune Dysregulation inAntioxidants (Basel, Switzerland) · 2026Article
- The Genetic Architecture of Venom Resistance: A Novel Approach to Target Identification and Coevolutionary Discovery.Molecular biology and evolution · 2026Article
- Shielded by the dead: how killed bacteria shape the dynamics and evolution of innate immunity.bioRxiv : the preprint server for biology · 2026Article
- Trade-off between antibacterial immune defense and oogenesis progression in female Drosophila melanogaster.Genetics · 2025Article
- The effects of mating and blood feeding on the immune defense of female Aedes aegypti mosquitoes.PLoS neglected tropical diseases · 2025Article
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- Single Amino Acid Changes Impact the Ability ofACS omega · 2025Article
- Reciprocal costs of infection and reproduction inBiology letters · 2025Article
- Chronic bacterial infections exert metabolic costs in Drosophila melanogaster.The Journal of experimental biology · 2025Article
- Ovariole number does not predict reproductive output or trade-off with immunity in Drosophila melanogaster.PloS one · 2025Article
- Transiently restricting individual amino acids protectsOpen biology · 2024Article
- High sugar diets can increase susceptibility to bacterial infection in Drosophila melanogaster.PLoS pathogens · 2024Article
- Impact of Chronic Infection on Resistance and Tolerance to Secondary Infection in Drosophila melanogaster.Infection and immunity · 2023Article
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- A single mating is sufficient to induce persistent reduction of immune defense in mated female Drosophila melanogaster.Journal of insect physiology · 2022Article
- Mutations ofInternational journal of molecular sciences · 2022Article
- Inherent constraints on a polyfunctional tissue lead to a reproduction-immunity tradeoff.BMC biology · 2022Article
- A Non-Nuclear NF-κB Modulates Alcohol Sensitivity But Not Immunity.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
The fruit fly Drosophila melanogaster is one of the premier model organisms for studying the function and evolution of immune defense. Many aspects of innate immunity are conserved between insects and mammals, and since Drosophila can readily be genetically and experimentally manipulated, they are powerful for studying immune system function and the physiological consequences of disease. The procedure demonstrated here allows infection of flies by introduction of bacteria directly into the body cavity, bypassing epithelial barriers and more passive forms of defense and allowing focus on systemic infection. The procedure includes protocols for the measuring rates of host mortality, systemic pathogen load, and degree of induction of the host immune system. This infection procedure is inexpensive, robust and quantitatively repeatable, and can be used in studies of functional genetics, evolutionary life history, and physiology.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.