Evidence map›Paper›PMID 25992369›Full record

ReviewAnnals of translational medicine2015

Body fluid biomarkers in Alzheimer's disease.

Huan Lu, Xi-Chen Zhu, Teng Jiang, Jin-Tai Yu, Lan Tan

Erratum issuedAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Annals of translational medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Review
  6. Plasma Biomarkers: Potent Screeners of Alzheimer's Disease.American journal of Alzheimer's disease and other dementias · 2019
    Review
  7. Article
  8. Tau in neurodegenerative disease.Annals of translational medicine · 2018
    Review
  9. Review
  10. Review
  11. Article
  12. Immunotherapy with Aducanumab Restores Calcium Homeostasis in Tg2576 Mice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016
    Article
  13. Erratum to Body fluid biomarkers in Alzheimer's disease.Annals of translational medicine · 2016
    Article
  14. Article
  15. [Anesthesia and Alzheimer disease - Current perceptions].Brazilian journal of anesthesiology (Elsevier)
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Huan Lu1 Department of Neurology, Qingdao Municipal Hospital, Nanjing Medical University, Nanjing 210029, China ; 2 Department of Neurology, Nanjing First Hospital, Nanjing Medical University, Nanjing 210029, China ; 3 Department of Neurology, Qingdao Municipal Hospital, School of Medicine, Qingdao University, Qingdao 266001, China ; 4 Memory and Aging Center, Department of Neurology, University of California, San Francisco, CA 94158, USA.
Xi-Chen Zhu1 Department of Neurology, Qingdao Municipal Hospital, Nanjing Medical University, Nanjing 210029, China ; 2 Department of Neurology, Nanjing First Hospital, Nanjing Medical University, Nanjing 210029, China ; 3 Department of Neurology, Qingdao Municipal Hospital, School of Medicine, Qingdao University, Qingdao 266001, China ; 4 Memory and Aging Center, Department of Neurology, University of California, San Francisco, CA 94158, USA.
Teng Jiang1 Department of Neurology, Qingdao Municipal Hospital, Nanjing Medical University, Nanjing 210029, China ; 2 Department of Neurology, Nanjing First Hospital, Nanjing Medical University, Nanjing 210029, China ; 3 Department of Neurology, Qingdao Municipal Hospital, School of Medicine, Qingdao University, Qingdao 266001, China ; 4 Memory and Aging Center, Department of Neurology, University of California, San Francisco, CA 94158, USA.
Jin-Tai Yu1 Department of Neurology, Qingdao Municipal Hospital, Nanjing Medical University, Nanjing 210029, China ; 2 Department of Neurology, Nanjing First Hospital, Nanjing Medical University, Nanjing 210029, China ; 3 Department of Neurology, Qingdao Municipal Hospital, School of Medicine, Qingdao University, Qingdao 266001, China ; 4 Memory and Aging Center, Department of Neurology, University of California, San Francisco, CA 94158, USA.
Lan Tan1 Department of Neurology, Qingdao Municipal Hospital, Nanjing Medical University, Nanjing 210029, China ; 2 Department of Neurology, Nanjing First Hospital, Nanjing Medical University, Nanjing 210029, China ; 3 Department of Neurology, Qingdao Municipal Hospital, School of Medicine, Qingdao University, Qingdao 266001, China ; 4 Memory and Aging Center, Department of Neurology, University of California, San Francisco, CA 94158, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A heterogeneous and slowly progressive disease with extracellular amyloid-β (Aβ) deposits and intracellular hyperphosphorylated tau protein aggregates, Alzheimer's disease (AD) is already a hard nut to crack, featured with cognitive decline and memory lapse. Body fluid biomarkers are proved to be useful in exploring further study of AD, might benefit for a full comprehension of the etiopathogenesis, an improved precision of the prognosis and diagnosis, and a positive response of treatments. The cerebrospinal fluid biomarkers Aβ, total tau, and hyperphosphorylated tau reflect the main pathologic changes of AD. We also review data from several novel biomarkers, such as, β-site APP cleaving enzyme 1, soluble amyloid precursor proteins α and β, soluble Aβ oligomers and so on, which are associated with the occurrence and deterioration of this disease and couldn't be ignored. The rationale for the clinical use of those biomarkers, the challenges faced with and the properties of the most appropriate biomarkers are also summarized in the paper. We aim to find several ideal biomarkers to improve the diagnosis and optimize the treatment respectively.

Indexed as

Alzheimer’s disease (AD)amyloid-β (Aβ)biomarkerstau proteinβ-site APP cleaving enzyme 1 (BACE1)

Identifiers

PMID25992369
PMCPMC4402605

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.