ArticleAnnals of translational medicine2015
The sterile and tolerogenic fetal niche does not restrict the generation of CD4 T memory cells.
Article in Annals of translational medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Abstract
T-cell activation requires a sequence of signals derived from co-stimulatory receptors and from immunogens that may or may not be of infectious origin. This scenario provides the threshold of inflammatory stimulus needed for the induction of antigen-specific T cell responses. One of the dogmas of immunology stipulates that the activation of T lymphocytes is prevented in immunosuppressed or tolerogenic environments. However, it was shown recently that a healthy uterine environment that is considered sterile, therefore not exposed to infection, is capable of generating T memory cells with the capacity to differentiate lineage-specific inflammatory effector T-cell responses. The implications of this finding are discussed in this editorial.
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