ReviewOncology reviews2014
Epithelioid hemangioendothelioma: an overview and update on a rare vascular tumor.
Review in Oncology reviews, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06680401 (The Evaluation of Cytokines and Hormones as Biomarkers for Epithelioid Haemangioendothelioma and Generation of Patient-derived Preclinical Models to Assess the Activity of Anticancer Agents and Validate Novel Therapeutic Targets), which is not on this map. Cited by 153 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Evaluation of Cytokines and Hormones as Biomarkers for Epithelioid Haemangioendothelioma and Generation of Patient-derived Preclinical Models to Assess the Activity of Anticancer Agents and Validate Novel Therapeutic Targets
Who cites it
153 citing papers in PubMed.
- A Single-Arm Phase 2 Trial of Trametinib in Patients with Locally Advanced or Metastatic Epithelioid Hemangioendothelioma.Clinical cancer research : an official journal of the American Association for Cancer Research · 2024Trial
- Article
- Pulmonary epithelioid hemangioendothelioma with pleural dissemination: a case report of prolonged diagnostic delay and the role of surgical biopsy.BMC pulmonary medicine · 2026Article
- Characteristics of patients with epithelioid hemangioendothelioma (EHE): a retrospective analysis of the Charité- Universitätsmedizin Berlin.Journal of cancer research and clinical oncology · 2026Article
- An epithelioid hemangioendothelioma with a novel RREB1::TFE3 gene fusion.Virchows Archiv : an international journal of pathology · 2026Article
- Pathological complete remission of pulmonary epithelioid hemangioendothelioma: a case report and literature review.Journal of cardiothoracic surgery · 2026Review
- One in One Million-A Case of Pleural Disease.Interdisciplinary cardiovascular and thoracic surgery · 2026Article
- A Rare Finding of Pulmonary Epithelioid Hemangioendothelioma.Case reports in pathology · 2026Article
- Primary Vaginal Epithelioid Haemangioendothelioma with Pulmonary Metastasis:Sultan Qaboos University medical journal · 2026Review
- Disseminated hepatic epithelioid hemangioendothelioma with multiorgan metastases achieving long-term stability with Pazopanib: a case report.Frontiers in oncology · 2026Article
- A 76-year-old man with hemoptysis and a groin nodule: A case report.SAGE open medical case reports · 2026Article
- Epithelioid Hemangioendothelioma With a Novel Chromosomal Deletion and an Aggressive Clinical Course: A Case Report and Literature Review.Case reports in oncological medicine · 2026Article
- Successful management of recurrent multiple intracerebral TFE3-rearranged epithelioid hemangioendothelioma with repeated intervention and active surveillance: illustrative case.Journal of neurosurgery. Case lessons · 2025Article
- A Comprehensive Approach to Treating Epithelioid Hemangioendothelioma of the Auricle: A Case Report.Cureus · 2025Article
- Article
- Radiation Therapy for Maxillary Sinus Epithelioid Hemangioendothelioma: A Case Report and Literature Review.Cureus · 2025Article
- Hepatic epithelioid hemangioendothelioma managed with minimally invasive surgery: A case report.World journal of clinical cases · 2025Article
- Article
- First-line pazopanib in patients with metastatic epithelioid hemangioendothelioma: a retrospective single-center analysis.Journal of cancer research and clinical oncology · 2025Article
- Epithelioid hemangioendothelioma of the anterior mediastinum.Indian journal of thoracic and cardiovascular surgery · 2025Article
93 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Epithelioid hemangioendothelioma is a rare vascular tumor, described for the first time in 1975 by Dail and Liebow as an aggressive bronchoalveolar cell carcinoma. The etiology is still a dilemma. Studies about suggestive hypothesis are ongoing. Most of the times it affects lung, liver and bones, although this kind of tumor may involve the head and neck area, breast, lymph nodes, mediastinum, brain and meninges, the spine, skin, abdomen and many other sites. Because of its heterogeneous presentation, as it represents less than 1% of all the vascular tumors, it is often misdiagnosed and not suitably treated, leading to a poor prognosis in some cases. Over 50-76% of the patients are asymptomatic. A small number of them complains respiratory symptoms. Bone metastases might cause pathological fractures or spine compression, if they arise in vertebrae. Imaging is necessary to determine morphological data, the involvement of surrounding tissues, and potentially the cleavage plan. It is important to recognize the expression of vascular markers (Fli-1 and CD31 are endothelial-specific markers), and the microscopic evidence of vascular differentiation to make a correct diagnosis, as many pulmonary diseases show multiple nodular lesions. Because of its rarity, there is no standard for treatment. We focused on radiotherapy as a good therapeutic option: despite the poor prognosis, evidence is in favor of radiotherapy which offers local pain control with good tolerance and better quality of life at least at a one-year follow-up in most of cases. Further studies are needed to establish the standard radiation dose to be used for locoregional control of such a complex and extremely rare disease.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.