Evidence map›Paper›PMID 25992241›Full record

ReviewOncology reviews2014

Bisphosphonate-related osteonecrosis of the jaw: specificities.

Siri Paulo, Ana Margarida Abrantes, Mafalda Laranjo, Lina Carvalho, Arménio Serra, Maria Filomena Botelho, Manuel Marques Ferreira

Open access · goldAbstract readReview
In one paragraph

Review in Oncology reviews, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 1 pooled it
3.1field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 1 synthesis or guideline pooled it, 46 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Siri PauloFaculty of Medicine, Coimbra University , Portugal.
Ana Margarida AbrantesFaculty of Medicine, Coimbra University , Portugal.
Mafalda LaranjoFaculty of Medicine, Coimbra University , Portugal.
Lina CarvalhoFaculty of Medicine, Coimbra University , Portugal.
Arménio SerraFaculty of Science and Technology, Coimbra University , Portugal.
Maria Filomena BotelhoFaculty of Medicine, Coimbra University , Portugal.
Manuel Marques FerreiraFaculty of Medicine, Coimbra University , Portugal.
University of Coimbra · PT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Bisphosphonate-related osteonecrosis of the jaws (BRONJ) is a severe complication that has recently emerged in patients treated with intravenous bisphosphonates for malignant diseases. This complication usually presents after a minor local trauma during a dental treatment. Several etiopathogenic mechanisms of this pathological condition have been proposed, but no model can explain all morphological changes observed at the macroscopic and microscopic level. BRONJ is likely to be related to direct toxicity in the bone and soft tissue cells, due to nitrogen-containing bisphosphonates. This review elucidates the clinical indications and mechanism of action of bisphosphonates, reports some clinical diagnostic criteria for BRONJ, describe the histopathological criteria for BRONJ diagnosis, the potential triggering pathways and the available treatment strategies.

Indexed as

bisphosphonatebonejawosteonecrosissoft tissues

Identifiers

PMID25992241
PMCPMC4419650
OpenAlexW2095193617

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.