ReviewInternational archives of otorhinolaryngology2014
Laryngopharyngeal reflux: diagnosis, treatment, and latest research.
Review in International archives of otorhinolaryngology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 61 papers, 5 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
61 citing papers in PubMed, 5 syntheses or guidelines pooled it, 158 citations in OpenAlex.
- Alginates and laryngopharyngeal reflux: where we stand. A systematic review.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2025Pooled it
- Relationship Between Laryngopharyngeal Reflux, Gastroesophageal Reflux Disease, and Dental Erosion in Adult Populations: A Systematic Review.Digestive diseases and sciences · 2025Pooled it
- Association of Heterotopic Gastric Mucosa in the Upper Esophagus (HGMUE) with Pharyngolaryngeal Symptoms: A Systematic Review and Meta-Analysis.Digestive diseases and sciences · 2024Pooled it
- Meta-analysis of Proton Pump Inhibitors in the Treatment of Pharyngeal Reflux Disease.Computational and mathematical methods in medicine · 2022Pooled it
- Pepsin in Saliva as a Diagnostic Marker for Gastroesophageal Reflux Disease: A Meta-Analysis.Medical science monitor : international medical journal of experimental and clinical research · 2018Pooled it
- The Effect of Topical Anesthesia on the Phonation Process During High-Speed Digital Imaging Laryngoscopy in Patients with Laryngopharyngeal Reflux: A Randomized, Double-Blind, Placebo-Controlled Crossover Trial.Medicina (Kaunas, Lithuania) · 2026Trial
- Modulation of Pepsin-Mediated Inflammatory Responses in Vocal Cord Epithelial Cells by Amprenavir.The Laryngoscope · 2026Article
- Long-Term Postoperative Swallowing Findings After Carbon Dioxide Laser Transverse Posterior Cordotomy in Bilateral Vocal Fold Paralysis: A Retrospective Cross-sectional FEES Study.Turkish archives of otorhinolaryngology · 2026Article
- Bridging the gap from mechanism to clinic: a translational perspective on taVNS for gastrointestinal disorders.Frontiers in neuroscience · 2026Review
- Reducing the Duration of 24-Hour Multichannel Intraluminal Impedance-pH Monitoring for Laryngopharyngeal Reflux.Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery · 2025Article
- Effect of Proton Pump Inhibitor on Quality of Life of Patients with Laryngopharyngeal Reflux.Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India · 2025Article
- A case of laryngopharyngeal reflux: CT characterization in the acute setting.Radiology case reports · 2025Article
- Scientometric analysis of trends in research in laryngopharyngeal reflux.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2025Article
- The Inhibitory Effect ofInternational journal of molecular sciences · 2024Article
- Laryngopharyngeal reflux: knowledge, attitudes, and practices among primary healthcare physicians.Acta otorhinolaryngologica Italica : organo ufficiale della Societa italiana di otorinolaringologia e chirurgia cervico-facciale · 2024Article
- Laryngopharyngeal Reflux Pathophysiology, Clinical Presentation, and Management: A Narrative Review.Cureus · 2024Review
- Effect of Laryngopharyngeal Reflux Disease on Middle Ear Function: A Case-Control Study.Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India · 2024Article
- Reflux Symptom Index (RSI), Videolaryngostroboscopy and Voice Analysis: A Triad of Non-Invasive Tools to Study Treatment Outcomes of Laryngopharyngeal Reflux Disease (LPRD).Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India · 2024Article
- Determination of pepsin in human saliva using pepsin-susceptible peptide reporter and colorimetric dipstick assay: a prospective, cross-sectional study.Mikrochimica acta · 2024Article
- Narrative review of relationship between chronic cough and laryngopharyngeal reflux.Frontiers in medicine · 2024Review
1 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction Laryngopharyngeal reflux (LPR) is a highly prevalent disease and commonly encountered in the otolaryngologist's office. Objective To review the literature on the diagnosis and treatment of LPR. Data Synthesis LPR is associated with symptoms of laryngeal irritation such as throat clearing, coughing, and hoarseness. The main diagnostic methods currently used are laryngoscopy and pH monitoring. The most common laryngoscopic signs are redness and swelling of the throat. However, these findings are not specific of LPR and may be related to other causes or can even be found in healthy individuals. Furthermore, the role of pH monitoring in the diagnosis of LPR is controversial. A therapeutic trial with proton pump inhibitors (PPIs) has been suggested to be cost-effective and useful for the diagnosis of LPR. However, the recommendations of PPI therapy for patients with a suspicion of LPR are based on the results of uncontrolled studies, and high placebo response rates suggest a much more complex and multifactorial pathophysiology of LPR than simple acid reflux. Molecular studies have tried to identify biomarkers of reflux such as interleukins, carbonic anhydrase, E-cadherin, and mucin. Conclusion Laryngoscopy and pH monitoring have failed as reliable tests for the diagnosis of LPR. Empirical therapy with PPIs is widely accepted as a diagnostic test and for the treatment of LPR. However, further research is needed to develop a definitive diagnostic test for LPR.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.