ArticleThe Plant cell2015
Wheat Stripe Rust Resistance Protein WKS1 Reduces the Ability of the Thylakoid-Associated Ascorbate Peroxidase to Detoxify Reactive Oxygen Species.
Article in The Plant cell, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 78 papers.
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Who cites it
78 citing papers in PubMed, 150 citations in OpenAlex.
- Wheat transcriptome changes in response to the black stem rust pathogen (Puccinia graminis f. sp. tritici).BMC biotechnology · 2026Article
- Current Status and Future Direction of the High-Temperature Resistance in Wheat to Control Stripe Rust.Molecular plant pathology · 2025Review
- TaWAKL8-2B, a wall-associated receptor-like kinase, mediates wheat rust resistance by linalool and ROS accumulation.Stress biology · 2025Article
- The important role of chloroplasts in plant immunity.Plant communications · 2025Review
- Suppressing wheat sucrose phosphate synthase 1-B protects wheat against stripe rust.Journal of advanced research · 2025Article
- Wheat Small GTPase Gene TaRABH1bL Is Involved in High-Temperature All-Stage Resistance to Puccinia striiformis f. sp. tritici.Molecular plant pathology · 2025Article
- The multifunctional ascorbate peroxidase MoApx1 secreted by Magnaporthe oryzae mediates the suppression of rice immunity.The Plant cell · 2025Article
- Genetic engineering, including genome editing, for enhancing broad-spectrum disease resistance in crops.Plant communications · 2025Review
- Integrated transcriptome and metabolome analyses reveals the mechanisms of function loss ofFrontiers in plant science · 2025Article
- Genome-wide association studies for identification of stripe rust resistance loci in diverse wheat genotypes.Frontiers in plant science · 2025Article
- ClBeclin1 Positively Regulates Citrus Defence Against Citrus Yellow Vein Clearing Virus Through Mediating Autophagy-Dependent Degradation of ClAPX1.Molecular plant pathology · 2024Article
- Arabidopsis PROTODERMAL FACTOR2 binds lysophosphatidylcholines and transcriptionally regulates phospholipid metabolism.The New phytologist · 2024Article
- Phosphatidylcholine Transfer Protein OsPCTP Interacts with Ascorbate Peroxidase OsAPX8 to Regulate Bacterial Blight Resistance in Rice.International journal of molecular sciences · 2024Article
- Structure, biogenesis, and evolution of thylakoid membranes.The Plant cell · 2024Review
- Genome-wide association study identifies novel loci and candidate genes for rust resistance in wheat (Triticum aestivum L.).BMC plant biology · 2024Article
- The ascorbate-glutathione cycle coming of age.Journal of experimental botany · 2024Review
- Fine mapping ofFrontiers in plant science · 2024Article
- HD-Zip IV transcription factors: Drivers of epidermal cell fate integrate metabolic signals.Current opinion in plant biology · 2023Review
- Suppression of ZEAXANTHIN EPOXIDASE 1 restricts stripe rust growth in wheat.Plant communications · 2023Article
- Novel insight into functions of ascorbate peroxidase in higher plants: More than a simple antioxidant enzyme.Redox biology · 2023Review
18 more citing papers are in PubMed but not listed here.
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Authors and funding
18 authors at 9 institutions in 5 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Stripe rust is a devastating fungal disease of wheat caused by Puccinia striiformis f. sp tritici (Pst). The WHEAT KINASE START1 (WKS1) resistance gene has an unusual combination of serine/threonine kinase and START lipid binding domains and confers partial resistance to Pst. Here, we show that wheat (Triticum aestivum) plants transformed with the complete WKS1 (variant WKS1.1) are resistant to Pst, whereas those transformed with an alternative splice variant with a truncated START domain (WKS1.2) are susceptible. WKS1.1 and WKS1.2 preferentially bind to the same lipids (phosphatidic acid and phosphatidylinositol phosphates) but differ in their protein-protein interactions. WKS1.1 is targeted to the chloroplast where it phosphorylates the thylakoid-associated ascorbate peroxidase (tAPX) and reduces its ability to detoxify peroxides. Increased expression of WKS1.1 in transgenic wheat accelerates leaf senescence in the absence of Pst. Based on these results, we propose that the phosphorylation of tAPX by WKS1.1 reduces the ability of the cells to detoxify reactive oxygen species and contributes to cell death. This response takes several days longer than typical hypersensitive cell death responses, thus allowing the limited pathogen growth and restricted sporulation that is characteristic of the WKS1 partial resistance response to Pst.
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