ArticleThe Plant cell2015
The Arabidopsis SWI2/SNF2 Chromatin Remodeling ATPase BRAHMA Targets Directly to PINs and Is Required for Root Stem Cell Niche Maintenance.
Article in The Plant cell, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers.
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Who cites it
56 citing papers in PubMed, 103 citations in OpenAlex.
- Abscisic acid-regulated stability of CmABF1 and CmBRM modulates salt tolerance in chrysanthemum via epigenetic regulation ofScience advances · 2026Article
- BRAHMA represses STOP1-NRT1.1 module to control plant rhizosphere alkalization and acid stress adaptation.Nature communications · 2026Article
- The LFR-SWI/SNF complex: A chromatin wrench safeguarding cellular quiescence in theProceedings of the National Academy of Sciences of the United States of America · 2025Article
- A comprehensive analysis to speculate the role of trithorax genes in photoperiod-mediated tuberization in potato and comparison with storage root crops.BMC plant biology · 2025Article
- BAF60/SWP73 subunits define subclasses of SWI/SNF chromatin remodelling complexes in Arabidopsis.The New phytologist · 2025Article
- Epigenetics and plant hormone dynamics: a functional and methodological perspective.Journal of experimental botany · 2024Review
- Chromatin sensing: integration of environmental signals to reprogram plant development through chromatin regulators.Journal of experimental botany · 2024Review
- ATP Hydrolases Superfamily Protein 1 (ASP1) Maintains Root Stem Cell Niche Identity through Regulating Reactive Oxygen Species Signaling inPlants (Basel, Switzerland) · 2024Article
- BCL7A and BCL7B potentiate SWI/SNF-complex-mediated chromatin accessibility to regulate gene expression and vegetative phase transition in plants.Nature communications · 2024Article
- Article
- Gibberellin signaling modulates flowering via the DELLA-BRAHMA-NF-YC module in Arabidopsis.The Plant cell · 2023Article
- Spotlight on Plant Bromodomain Proteins.Biology · 2023Review
- The SMC5/6 complex subunit MMS21 regulates stem cell proliferation in rice.Plant cell reports · 2023Article
- Organization, genomic targeting, and assembly of three distinct SWI/SNF chromatin remodeling complexes in Arabidopsis.The Plant cell · 2023Article
- Genome-Wide Identification and Characterization of the Soybean Snf2 Gene Family and Expression Response to Rhizobia.International journal of molecular sciences · 2023Article
- Review
- A Green Light to Switch on Genes: Revisiting Trithorax on Plants.Plants (Basel, Switzerland) · 2022Review
- The plant stem-cell niche and pluripotency: 15 years of an epigenetic perspective.Frontiers in plant science · 2022Article
- Article
- A Systems Biology Approach to Identify Essential Epigenetic Regulators for Specific Biological Processes in Plants.Plants (Basel, Switzerland) · 2021Article
Corrections and comments
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Authors and funding
12 authors at 6 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BRAHMA (BRM), a SWI/SNF chromatin remodeling ATPase, is essential for the transcriptional reprogramming associated with development and cell differentiation in Arabidopsis thaliana. In this study, we show that loss-of-function mutations in BRM led to defective maintenance of the root stem cell niche, decreased meristematic activity, and stunted root growth. Mutations of BRM affected auxin distribution by reducing local expression of several PIN-FORMED (PIN) genes in the stem cells and impaired the expression of the stem cell transcription factor genes PLETHORA (PLT1) and PLT2. Chromatin immunoprecipitation assays showed that BRM could directly target to the chromatin of PIN1, PIN2, PIN3, PIN4, and PIN7. In addition, genetic interaction assays indicate that PLTs acted downstream of BRM, and overexpression of PLT2 partially rescued the stem cell niche defect of brm mutants. Taken together, these results support the idea that BRM acts in the PLT pathway to maintain the root stem cell niche by altering the expression of PINs.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.