ArticleMagnetic resonance in medicine2016
Cardiac perfusion imaging using hyperpolarized (13)C urea using flow sensitizing gradients.
Article in Magnetic resonance in medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed, 45 citations in OpenAlex.
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- 3D quantitative myocardial perfusion imaging with hyperpolarized HP001(bis-1,1-(hydroxymethyl)-[1-Magnetic resonance in medicine · 2025Article
- Investigating the origin of theNMR in biomedicine · 2024Article
- Assessing the effect of anesthetic gas mixtures on hyperpolarizedMagnetic resonance in medicine · 2022Article
- Investigating the Feasibility of In Vivo Perfusion Imaging Methods for Spinal Cord Using Hyperpolarized [Molecular imaging and biology · 2022Article
- [HyperpolarizedRadiologie (Heidelberg, Germany) · 2022Review
- Clinical translation of hyperpolarizedMagnetic resonance in medicine · 2022Article
- Zero-Field NMR of Urea: Spin-Topology Engineering by Chemical Exchange.The journal of physical chemistry letters · 2021Article
- Characterization and compensation ofMagnetic resonance in medicine · 2021Article
- Article
- Fast Imaging for Hyperpolarized MR Metabolic Imaging.Journal of magnetic resonance imaging : JMRI · 2021Review
- A 3D hybrid-shot spiral sequence for hyperpolarizedMagnetic resonance in medicine · 2021Article
- A variable resolution approach for improved acquisition of hyperpolarizedMagnetic resonance in medicine · 2020Article
- Measuring the link between cardiac mechanical function and metabolism during hyperpolarizedMagnetic resonance imaging · 2020Article
- Clinical Cardiovascular Applications of Hyperpolarized Magnetic Resonance.Cardiovascular drugs and therapy · 2020Review
- HyperpolarizedRadiology · 2019Review
- Quantitative myocardial first-pass cardiovascular magnetic resonance perfusion imaging using hyperpolarized [1-Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · 2018Article
- A non-synthetic approach to extending the lifetime of hyperpolarized molecules using DJournal of magnetic resonance (San Diego, Calif. : 1997) · 2018Article
- Placental physiology monitored by hyperpolarized dynamicProceedings of the National Academy of Sciences of the United States of America · 2018Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
purposeTo demonstrate the feasibility of imaging the first passage of a bolus of hyperpolarized (13)C urea through the rodent heart using flow-sensitizing gradients to reduce signal from the blood pool.
methodsA flow-sensitizing bipolar gradient was optimized to reduce the bright signal within the cardiac chambers, enabling improved contrast of the agent within the tissue capillary bed. The gradient was incorporated into a dynamic golden angle spiral (13)C imaging sequence. Healthy rats were scanned during rest (n = 3) and under adenosine stress-induced hyperemia (n = 3).
resultsA two-fold increase in myocardial perfusion relative to rest was detected during adenosine stress-induced hyperemia, consistent with a myocardial perfusion reserve of two in rodents.
conclusionThe new pulse sequence was used to obtain dynamic images of the first passage of hyperpolarized (13)C urea in the rodent heart, without contamination from bright signal within the neighboring cardiac lumen. This probe of myocardial perfusion is expected to enable new hyperpolarized (13)C studies in which the cardiac metabolism/perfusion mismatch can be identified. Magnetic Resonance in Medicine published by Wiley Periodicals, Inc. on behalf of International Society for Magnetic Resonance.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.