ReviewTrends in parasitology2015
A worm of one's own: how helminths modulate host adipose tissue function and metabolism.
Review in Trends in parasitology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Effects of helminths and anthelmintic treatment on cardiometabolic diseases and risk factors: A systematic review.PLoS neglected tropical diseases · 2023Pooled it
- Intestinal helminthFrontiers in microbiology · 2025Article
- Article
- Diminished Circulating Levels of Angiogenic Factors and Rage Ligands in Helminth-Diabetes Comorbidity and Reversal Following Anthelmintic Treatment.The Journal of infectious diseases · 2021Article
- The effects of helminth infections against type 2 diabetes.Parasitology research · 2021Review
- Rapidly declining body temperature in a tropical human population.Science advances · 2020Article
- Safety and tolerability of experimental hookworm infection in humans with metabolic disease: study protocol for a phase 1b randomised controlled clinical trial.BMC endocrine disorders · 2019Article
- Metabolic Consequences of Concomitant Strongyloides stercoralis Infection in Patients With Type 2 Diabetes Mellitus.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2019Article
- The impact of a helminth-modified microbiome on host immunity.Mucosal immunology · 2018Review
- Helminth infection protects against high fat diet-induced obesity via induction of alternatively activated macrophages.Scientific reports · 2018Article
- Review
- Côte d'Ivoire Dual Burden of Disease (CoDuBu): Study Protocol to Investigate the Co-occurrence of Chronic Infections and Noncommunicable Diseases in Rural Settings of Epidemiological Transition.JMIR research protocols · 2017Article
- IGF1 Shapes Macrophage Activation in Response to Immunometabolic Challenge.Cell reports · 2017Article
- New Data on Human Macrophages Polarization byFrontiers in immunology · 2017Article
- Regulation of metabolic health and adipose tissue function by group 2 innate lymphoid cells.European journal of immunology · 2016Review
- Schistosome-Derived Molecules as Modulating Actors of the Immune System and Promising Candidates to Treat Autoimmune and Inflammatory Diseases.Journal of immunology research · 2016Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
Parasitic helminths have coexisted with human beings throughout time. Success in eradicating helminths has limited helminth-induced morbidity and mortality but is also correlated with increasing rates of 'western' diseases, including metabolic syndrome and type 2 diabetes. Recent studies in mice describe how type 2 immune cells, traditionally associated with helminth infection, maintain adipose tissue homeostasis and promote adipose tissue beiging, protecting against obesity and metabolic dysfunction. Here, we review these studies and discuss how helminths and helminth-derived molecules may modulate these physiologic pathways to improve metabolic functions in specific tissues, such as adipose and liver, as well as at the whole-organism level.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.