ReviewBiogerontology2016
Complex systems dynamics in aging: new evidence, continuing questions.
Review in Biogerontology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 65 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
65 citing papers in PubMed.
- Physiological Age and Homeostatic Dysregulation Following Child Maltreatment in Youth.Molecular psychiatry · 2026Article
- Loss of tissue-state plasticity: a conceptual framework for age-associated regenerative failure.Inflammation and regeneration · 2026Review
- Mechanistic pathways between adult child education and late-life parental health outcomes: cross-national comparisons across the US, Mexico, and India.Social science & medicine (1982) · 2026Article
- Bat-Inspired Longevity: Immune Damage Management and Nutritional Modulation for Healthy Aging.International journal of molecular sciences · 2026Review
- Mitochondria at the heart of aging: structure, function, and failure.Journal of translational medicine · 2026Review
- Ageing was never a singular problem in biology: implications for mechanisms, measurements and interventions.Biogerontology · 2026Review
- Aging is not a disease: an evolutionary and comparative biological reappraisal.Biogerontology · 2026Review
- Statistical Methods in Aging Research: Improving Current Practices and Embracing Emerging Approaches.Annual review of statistics and its application · 2026Article
- The complicated relationship between inflammation and metabolic dysfunction.Journal of diabetes and metabolic disorders · 2025Review
- A novel information-theoretic approach reveals loss of effective biomolecular communication in aging muscle cells.The journals of gerontology. Series A, Biological sciences and medical sciences · 2025Article
- Harmonizing 10,000 connectomes: site-invariant representation learning for multi-site analysis of network connectivity and cognitive impairment.Journal of medical imaging (Bellingham, Wash.) · 2025Article
- A methodological framework for integrating model-guided medicine and multidimensional information management systems: application in anti-aging healthcare.International journal of computer assisted radiology and surgery · 2025Article
- Pre-Vaccination Immunotypes and Immune Entropy Are Indicators of Multiple Vaccine Responsiveness.Aging cell · 2025Article
- Modulating biological aging with food-derived signals: a systems and precision nutrition perspective.npj aging · 2025Review
- Systemic Rearrangement of the Heart Rhythm in the Process of Organism Aging: Spectral Analysis.Doklady. Biochemistry and biophysics · 2025Article
- Whole-body networks: a holistic approach for studying aging.GeroScience · 2025Article
- Healthy dietary patterns, biological aging, and kidney stones: evidence from NHANES 2007-2018.Frontiers in nutrition · 2025Article
- Efficacy of nutraceutical supplements containingFrontiers in veterinary science · 2025Article
- A method for in silico exploration of potential glioblastoma multiforme attractors using single-cell RNA sequencing.Scientific reports · 2024Article
- Exploring trajectories of functional decline and recovery among older adults: a data-driven approach.Scientific reports · 2024Article
5 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
Abstract
There have long been suggestions that aging is tightly linked to the complex dynamics of the physiological systems that maintain homeostasis, and in particular to dysregulation of regulatory networks of molecules. This review synthesizes recent work that is starting to provide evidence for the importance of such complex systems dynamics in aging. There is now clear evidence that physiological dysregulation--the gradual breakdown in the capacity of complex regulatory networks to maintain homeostasis--is an emergent property of these regulatory networks, and that it plays an important role in aging. It can be measured simply using small numbers of biomarkers. Additionally, there are indications of the importance during aging of emergent physiological processes, functional processes that cannot be easily understood through clear metabolic pathways, but can nonetheless be precisely quantified and studied. The overall role of such complex systems dynamics in aging remains an important open question, and to understand it future studies will need to distinguish and integrate related aspects of aging research, including multi-factorial theories of aging, systems biology, bioinformatics, network approaches, robustness, and loss of complexity.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.