ArticleClinical infectious diseases : an official publication of the Infectious Diseases Society of America2015
Field Evaluation of Capillary Blood Samples as a Collection Specimen for the Rapid Diagnosis of Ebola Virus Infection During an Outbreak Emergency.
Article in Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 27 citations in OpenAlex.
- Presence and Persistence of Ebola or Marburg Virus in Patients and Survivors: A Rapid Systematic Review.PLoS neglected tropical diseases · 2016Pooled it
- Evolving Landscape of Emerging Virus Diagnosis: Challenges and Innovations.Molecular biotechnology · 2026Review
- Optimizing Public Health Preparedness for Highly Infectious Diseases in Central Vietnam.Diagnostics (Basel, Switzerland) · 2022Article
- Rapid point-of-care testing for COVID-19: quality of supportive information for lateral flow serology assays.BMJ open · 2021Article
- Development and validation of an ELISA for a biomarker of thyroid dysfunction, thyroid peroxidase autoantibodies (TPO-Ab), in dried blood spots.Journal of physiological anthropology · 2020Article
- Article
- Determining the effect of different environmental conditions on Ebola virus viability in clinically relevant specimens.Emerging microbes & infections · 2018Article
- Operational Research during the Ebola Emergency.Emerging infectious diseases · 2017Article
- External quality assessment study for ebolavirus PCR-diagnostic promotes international preparedness during the 2014 - 2016 Ebola outbreak in West Africa.PLoS neglected tropical diseases · 2017Article
- Ebola virus disease and pregnancy: A review of the current knowledge of Ebola virus pathogenesis, maternal, and neonatal outcomes.Birth defects research · 2017Review
- Molecular Diagnostic Field Test for Point-of-Care Detection of Ebola Virus Directly From Blood.The Journal of infectious diseases · 2016Article
- Rapid Bedside Inactivation of Ebola Virus for Safe Nucleic Acid Tests.Journal of clinical microbiology · 2016Article
- The Point-of-Care Laboratory in Clinical Microbiology.Clinical microbiology reviews · 2016Review
- Performance of the GeneXpert Ebola Assay for Diagnosis of Ebola Virus Disease in Sierra Leone: A Field Evaluation Study.PLoS medicine · 2016Article
- Article
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Authors and funding
13 authors at 5 institutions in 6 countries.
Funding
Abstract
backgroundReliable reverse transcription polymerase chain reaction (RT-PCR)-based diagnosis of Ebola virus infection currently requires a blood sample obtained by intravenous puncture. During the current Ebola outbreak in Guinea, we evaluated the usability of capillary blood samples collected from fingersticks of patients suspected of having Ebola virus disease (EVD) for field diagnostics during an outbreak emergency.
methodsA total of 120 venous and capillary blood samples were collected from 53 patients admitted to the Ebola Treatment Centre in Guéckédou, Guinea, between July and August 2014. All sample specimens were analyzed by RT-PCR using the RealStar Filovirus Screen RT-PCR Kit 1.0 from altona Diagnostics (Germany). We compared samples obtained by venipuncture and those obtained by capillary blood sampling absorbed onto swab devices.
resultsThe resulting sensitivity and specificity of tests performed with capillary blood samples were 86.8% (95% confidence interval [CI], 71.9%-95.6%; 33/38 patients) and 100% (95% CI, 84.6%-100%; 22/22 patients), respectively.
conclusionsOur data suggest that capillary blood samples could serve as an alternative to venous blood samples for the diagnosis of EVD in resource-limited settings during a crisis. This can be of particular advantage in cases when venipuncture is difficult to perform-for example, with newborns and infants or when adult patients reject venipuncture for cultural or religious reasons.
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