Evidence map›Paper›PMID 25991416›Full record

ArticleStroke2015

Soluble Epoxide Hydrolase in Hydrocephalus, Cerebral Edema, and Vascular Inflammation After Subarachnoid Hemorrhage.

Dominic A Siler, Yosef A Berlow, Ayaka Kukino, Catherine M Davis, Jonathan W Nelson, Marjorie R Grafe, Hirohisa Ono, Justin S Cetas, Martin Pike, Nabil J Alkayed

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Stroke, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed, 1 pooled it
3.8field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 1 synthesis or guideline pooled it, 51 citations in OpenAlex.

  1. Pooled it
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  6. Enhancing cancer immunotherapy via inhibition of soluble epoxide hydrolase.Proceedings of the National Academy of Sciences of the United States of America · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Dominic A SilerFrom the Department of Anesthesiology and Perioperative Medicine, The Knight Cardiovascular Institute (D.A.S., C.M.D., J.W.N., M.R.G., N.J.A.), Department of Neurological Surgery (D.A.S., J.S.C.), Advanced Imaging Research Center (Y.A.B., A.K., M.P.), Oregon Health and Science University, Portland; Department of Neurosurgery, Nishijima Hospital, Numazu City, Sizuoka, Japan (H.O.); and Portland VA Medical Center, OR (J.S.C.).
Yosef A BerlowFrom the Department of Anesthesiology and Perioperative Medicine, The Knight Cardiovascular Institute (D.A.S., C.M.D., J.W.N., M.R.G., N.J.A.), Department of Neurological Surgery (D.A.S., J.S.C.), Advanced Imaging Research Center (Y.A.B., A.K., M.P.), Oregon Health and Science University, Portland; Department of Neurosurgery, Nishijima Hospital, Numazu City, Sizuoka, Japan (H.O.); and Portland VA Medical Center, OR (J.S.C.).
Ayaka KukinoFrom the Department of Anesthesiology and Perioperative Medicine, The Knight Cardiovascular Institute (D.A.S., C.M.D., J.W.N., M.R.G., N.J.A.), Department of Neurological Surgery (D.A.S., J.S.C.), Advanced Imaging Research Center (Y.A.B., A.K., M.P.), Oregon Health and Science University, Portland; Department of Neurosurgery, Nishijima Hospital, Numazu City, Sizuoka, Japan (H.O.); and Portland VA Medical Center, OR (J.S.C.).
Catherine M DavisFrom the Department of Anesthesiology and Perioperative Medicine, The Knight Cardiovascular Institute (D.A.S., C.M.D., J.W.N., M.R.G., N.J.A.), Department of Neurological Surgery (D.A.S., J.S.C.), Advanced Imaging Research Center (Y.A.B., A.K., M.P.), Oregon Health and Science University, Portland; Department of Neurosurgery, Nishijima Hospital, Numazu City, Sizuoka, Japan (H.O.); and Portland VA Medical Center, OR (J.S.C.).
Jonathan W NelsonFrom the Department of Anesthesiology and Perioperative Medicine, The Knight Cardiovascular Institute (D.A.S., C.M.D., J.W.N., M.R.G., N.J.A.), Department of Neurological Surgery (D.A.S., J.S.C.), Advanced Imaging Research Center (Y.A.B., A.K., M.P.), Oregon Health and Science University, Portland; Department of Neurosurgery, Nishijima Hospital, Numazu City, Sizuoka, Japan (H.O.); and Portland VA Medical Center, OR (J.S.C.).
Marjorie R GrafeFrom the Department of Anesthesiology and Perioperative Medicine, The Knight Cardiovascular Institute (D.A.S., C.M.D., J.W.N., M.R.G., N.J.A.), Department of Neurological Surgery (D.A.S., J.S.C.), Advanced Imaging Research Center (Y.A.B., A.K., M.P.), Oregon Health and Science University, Portland; Department of Neurosurgery, Nishijima Hospital, Numazu City, Sizuoka, Japan (H.O.); and Portland VA Medical Center, OR (J.S.C.).
Hirohisa OnoFrom the Department of Anesthesiology and Perioperative Medicine, The Knight Cardiovascular Institute (D.A.S., C.M.D., J.W.N., M.R.G., N.J.A.), Department of Neurological Surgery (D.A.S., J.S.C.), Advanced Imaging Research Center (Y.A.B., A.K., M.P.), Oregon Health and Science University, Portland; Department of Neurosurgery, Nishijima Hospital, Numazu City, Sizuoka, Japan (H.O.); and Portland VA Medical Center, OR (J.S.C.).
Justin S CetasFrom the Department of Anesthesiology and Perioperative Medicine, The Knight Cardiovascular Institute (D.A.S., C.M.D., J.W.N., M.R.G., N.J.A.), Department of Neurological Surgery (D.A.S., J.S.C.), Advanced Imaging Research Center (Y.A.B., A.K., M.P.), Oregon Health and Science University, Portland; Department of Neurosurgery, Nishijima Hospital, Numazu City, Sizuoka, Japan (H.O.); and Portland VA Medical Center, OR (J.S.C.).
Martin PikeFrom the Department of Anesthesiology and Perioperative Medicine, The Knight Cardiovascular Institute (D.A.S., C.M.D., J.W.N., M.R.G., N.J.A.), Department of Neurological Surgery (D.A.S., J.S.C.), Advanced Imaging Research Center (Y.A.B., A.K., M.P.), Oregon Health and Science University, Portland; Department of Neurosurgery, Nishijima Hospital, Numazu City, Sizuoka, Japan (H.O.); and Portland VA Medical Center, OR (J.S.C.).
Nabil J AlkayedFrom the Department of Anesthesiology and Perioperative Medicine, The Knight Cardiovascular Institute (D.A.S., C.M.D., J.W.N., M.R.G., N.J.A.), Department of Neurological Surgery (D.A.S., J.S.C.), Advanced Imaging Research Center (Y.A.B., A.K., M.P.), Oregon Health and Science University, Portland; Department of Neurosurgery, Nishijima Hospital, Numazu City, Sizuoka, Japan (H.O.); and Portland VA Medical Center, OR (J.S.C.). alkayedn@ohsu.edu.
Oregon Health & Science University · US

Funding

TIA-Induced Ischemic Tolerance via P450 EpoxygenaseR01NS044313 · NINDS · OREGON HEALTH & SCIENCE UNIVERSITY · PI ALKAYED, NABIL J · 2002 to 2015
$4.9M
Training in Translational Science and Cardiovascular MedicineT32HL094294 · NHLBI · OREGON HEALTH & SCIENCE UNIVERSITY · PI ALKAYED, NABIL J · 2009 to 2018
$3.5M
Mechanism of Vascular Dysfunction after Stroke in Postmenopausal FemaleR01NS070837 · NINDS · OREGON HEALTH & SCIENCE UNIVERSITY · PI ALKAYED, NABIL J · 2011 to 2015
$1.7M
Inhibition of Autophagy Enhances Anti-Angiogenic Efficacy in Intracranial GliomaR21CA167302 · NCI · OREGON HEALTH & SCIENCE UNIVERSITY · PI PIKE, MARTIN M · 2012 to 2013
$358k
Role of P450 Eicosanoids in Delayed Microvascular Spasm Following Subarachnoid HeF30HL108624 · NHLBI · OREGON HEALTH & SCIENCE UNIVERSITY · PI SILER, DOMINIC AARON · 2011 to 2015
$237k
NCI NIH HHS 1R21CA167302-0NCI NIH HHS R21 CA167302NHLBI NIH HHS F30 HL108624NHLBI NIH HHS T32 HL094294NINDS NIH HHS R01 NS044313NINDS NIH HHS R01 NS070837
6 · The paper itself

Abstract

background and purposeAcute communicating hydrocephalus and cerebral edema are common and serious complications of subarachnoid hemorrhage (SAH), whose causes are poorly understood. Using a mouse model of SAH, we determined whether soluble epoxide hydrolase (sEH) gene deletion protects against SAH-induced hydrocephalus and edema by increasing levels of vasoprotective eicosanoids and suppressing vascular inflammation.

methodsSAH was induced via endovascular puncture in wild-type and sEH knockout mice. Hydrocephalus and tissue edema were assessed by T2-weighted magnetic resonance imaging. Endothelial activation was assessed in vivo using T2*-weighted magnetic resonance imaging after intravenous administration of iron oxide particles linked to anti-vascular cell adhesion molecule-1 antibody 24 hours after SAH. Behavioral outcome was assessed at 96 hours after SAH with the open field and accelerated rotarod tests.

resultsSAH induced an acute sustained communicating hydrocephalus within 6 hours of endovascular puncture in both wild-type and sEH knockout mice. This was followed by tissue edema, which peaked at 24 hours after SAH and was limited to white matter fiber tracts. sEH knockout mice had reduced edema, less vascular cell adhesion molecule-1 uptake, and improved outcome compared with wild-type mice.

conclusionsGenetic deletion of sEH reduces vascular inflammation and edema and improves outcome after SAH. sEH inhibition may serve as a novel therapy for SAH.

Indexed as

AnimalsBrain EdemaEpoxide HydrolasesInflammationMaleMiceMice, Inbred C57BLMice, KnockoutSubarachnoid HemorrhageVasculitisEpoxide Hydrolasescommunicating hydrocephalusedemasubarachnoid hemorrhagevascular cell adhesion molecule-1

Identifiers

PMID25991416
PMCPMC4480190
OpenAlexW1910276728

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.