ArticleJournal of clinical hypertension (Greenwich, Conn.)2015
Arterial Stiffness and Peripheral and Central Blood Pressure in Patients With Sickle Cell Disease.
Article in Journal of clinical hypertension (Greenwich, Conn.), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 12 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Obesity in Pediatric Sickle Cell Disease: A New Phenomenon
The Relationship of Transcranial Doppler Velocity With Other Vascular Measurements in Children With Sickle Cell Anaemia
Low Systemic/High Local Exercise Load in Pediatric Sickle Cell Disease
Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Factors associated with blood pressure variation in sickle cell disease patients: a systematic review and meta-analyses.Expert review of hematology · 2022Pooled it
- Association Between Nitric Oxide, Oxidative Stress, Eryptosis, Red Blood Cell Microparticles, and Vascular Function in Sickle Cell Anemia.Frontiers in immunology · 2020Trial
- Cardiovascular consequences of sickle cell disease.Biophysics reviews · 2022Review
- Clinical characteristics and risk factors of relative systemic hypertension and hypertension among sickle cell patients in Cameroon.Frontiers in medicine · 2022Article
- Unmasking hypertension in children and adolescents with sickle/beta-thalassemia.Journal of clinical hypertension (Greenwich, Conn.) · 2020Article
- Association between renal function parameters, clinical severity score and mortality risk among adult Sudanese sickle anemia patients.American journal of blood research · 2020Article
- Prevalence of left ventricular diastolic dysfunction by cardiac magnetic resonance imaging in thalassemia major patients with normal left ventricular systolic function.BMC cardiovascular disorders · 2019Article
- Acacia Senegal (Gum Arabic) Supplementation Modulate Lipid Profile and Ameliorated Dyslipidemia among Sickle Cell Anemia Patients.Journal of lipids · 2019Article
- Risk factors of metabolic syndrome among adult Sudanese sickle cell anemia patients.BMC hematology · 2018Article
- Correlations of Arterial Stiffness and Augmentation Index With Metabolic Risk Factors in Patients With Type 2 Diabetes.Journal of clinical hypertension (Greenwich, Conn.) · 2016Article
- Arterial Stiffness in Special Populations.Journal of clinical hypertension (Greenwich, Conn.) · 2016Article
- Impact of relative systemic hypertension on the heart in sickle cell anaemia.Indian heart journalArticle
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Blood pressure (BP) in patients with sickle cell disease (SCD) has been reported to be lower than in persons in the general population. Data on arterial stiffness, which is an important risk factor for the progression of BP, are inconclusive for this patient population. Forty-five adult patients with SCD and 40 controls matched for sex, age, and body mass index were studied. Brachial systolic BP (SBP) and diastolic BP (DBP) were significantly lower in the patient group (SBP 115.1±13.8 mm Hg vs 121.9±11.3 mm Hg and DBP 68.5±8.0 mm Hg vs 80.6±9.1 mm Hg, P<.05, respectively). Augmentation index (AIx), however, was significantly higher in SCD patients compared with healthy controls (24.9±9.6 for patients vs 12.4±10.8 for controls, P<.001), while carotid femoral pulse wave velocity was comparable between the two groups. The study shows that mechanisms other than arterial elasticity are involved in the low BP phenotype of patients with SCD.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.