ArticleAging cell2015
Lgr5⁺ amacrine cells possess regenerative potential in the retina of adult mice.
Article in Aging cell, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 33 citations in OpenAlex.
- Age-Related Macular Degeneration: Therapeutic Strategies Based on Stem Cells.Stem cell reviews and reports · 2025Review
- A gene edited pig model for studying LGR5Frontiers in genome editing · 2024Review
- Trilogy Development of Proopiomelanocortin Neurons From Embryonic to Adult Stages in the Mice Retina.Frontiers in cell and developmental biology · 2021Article
- Mouse Retinal Cell Atlas: Molecular Identification of over Sixty Amacrine Cell Types.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- On the Generation and Regeneration of Retinal Ganglion Cells.Frontiers in cell and developmental biology · 2020Article
- Limitations and Promise of Retinal Tissue From Human Pluripotent Stem Cells for Developing Therapies of Blindness.Frontiers in cellular neuroscience · 2020Review
- Review
- Transcriptome Analysis Did Not Show Endogenous Stem Cell Characteristics in Murine Lgr5International journal of molecular sciences · 2019Article
- Immunohistological Study of Monkey Foveal Retina.Scientific reports · 2019Article
- Adult Stem Cells, Tools for Repairing the Retina.Current ophthalmology reports · 2019Article
- Ndr kinases regulate retinal interneuron proliferation and homeostasis.Scientific reports · 2018Article
- Leucine-rich G Protein-coupled Receptor-5 Is Significantly Increased in the Aqueous Humor of Human Eye with Proliferative Diabetic Retinopathy.Experimental neurobiology · 2018Article
- Dual extra-retinal origins of microglia in the model of retinal microglia repopulation.Cell discovery · 2018Article
- Evidence for a retinal progenitor cell in the postnatal and adult mouse.Stem cell research · 2017Article
- Transitional Progenitors during Vertebrate Retinogenesis.Molecular neurobiology · 2017Review
- Progress of stem/progenitor cell-based therapy for retinal degeneration.Journal of translational medicine · 2017Review
- Report on the National Eye Institute Audacious Goals Initiative: Replacement of Retinal Ganglion Cells from Endogenous Cell Sources.Translational vision science & technology · 2017Article
- Loss of Axin2 Causes Ocular Defects During Mouse Eye Development.Investigative ophthalmology & visual science · 2016Article
- Ocular Stem Cell Research from Basic Science to Clinical Application: A Report from Zhongshan Ophthalmic Center Ocular Stem Cell Symposium.International journal of molecular sciences · 2016Article
- LGR4 and LGR5 Regulate Hair Cell Differentiation in the Sensory Epithelium of the Developing Mouse Cochlea.Frontiers in cellular neuroscience · 2016Article
Corrections and comments
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Authors and funding
11 authors at 2 institutions in 1 country.
Funding
Abstract
Current knowledge indicates that the adult mammalian retina lacks regenerative capacity. Here, we show that the adult stem cell marker, leucine-rich repeat-containing G-protein-coupled receptor 5 (Lgr5), is expressed in the retina of adult mice. Lgr5(+) cells are generated at late stages of retinal development and exhibit properties of differentiated amacrine interneurons (amacrine cells). Nevertheless, Lgr5(+) amacrine cells contribute to regeneration of new retinal cells in the adult stage. The generation of new retinal cells, including retinal neurons and Müller glia from Lgr5(+) amacrine cells, begins in early adulthood and continues as the animal ages. Together, these findings suggest that the mammalian retina is not devoid of regeneration as previously thought. It is rather dynamic, and Lgr5(+) amacrine cells function as an endogenous regenerative source. The identification of such cells in the mammalian retina may provide new insights into neuronal regeneration and point to therapeutic opportunities for age-related retinal degenerative diseases.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.