ArticleOrigins of life and evolution of the biosphere : the journal of the International Society for the Study of the Origin of Life2015
Prebiotic alternatives to proteins: structure and function of hyperbranched polyesters.
Article in Origins of life and evolution of the biosphere : the journal of the International Society for the Study of the Origin of Life, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 17 citations in OpenAlex.
- Recent progress in primitive polyester synthesis and membraneless microdroplet assembly.Biophysics and physicobiology · 2023Article
- Geoelectrochemistry-driven alteration of amino acids to derivative organics in carbonaceous chondrite parent bodies.Nature communications · 2022Article
- Protoenzymes: The Case of Hyperbranched Polymer-Scaffolded ZnS Nanocrystals.Life (Basel, Switzerland) · 2020Article
- Polyesters as a Model System for Building Primitive Biologies from Non-Biological Prebiotic Chemistry.Life (Basel, Switzerland) · 2020Article
- Membraneless polyester microdroplets as primordial compartments at the origins of life.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Water vapor permeable polyurethane films based on the hyperbranched aminoethers of boric acid.RSC advances · 2019Article
- Wet-Dry Cycling Delays the Gelation of Hyperbranched Polyesters: Implications to the Origin of Life.Life (Basel, Switzerland) · 2019Article
- Re-conceptualizing the origins of life.Philosophical transactions. Series A, Mathematical, physical, and engineering sciences · 2017Article
- Protoenzymes: the case of hyperbranched polyesters.Philosophical transactions. Series A, Mathematical, physical, and engineering sciences · 2017Article
Corrections and comments
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Authors and funding
4 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Proteins are responsible multiple biological functions, such as ligand binding, catalysis, and ion channeling. This functionality is enabled by proteins' three-dimensional structures that require long polypeptides. Since plausibly prebiotic synthesis of functional polypeptides has proven challenging in the laboratory, we propose that these functions may have been initially performed by alternative macromolecular constructs, namely hyperbranched polymers (HBPs), during early stages of chemical evolution. HBPs can be straightforwardly synthesized in one-pot processes, possess globular structures determined by their architecture as opposed to folding in proteins, and have documented ligand binding and catalytic properties. Our initial study focuses on glycerol-citric acid HBPs synthesized via moderate heating in the dry state. The polymerization products consisted of a mixture of isomeric structures of varying molar mass as evidenced by NMR, mass spectrometry and size-exclusion chromatography. Addition of divalent cations during polymerization resulted in increased incorporation of citric acid into the HBPs and the possible formation of cation-oligomer complexes. The chelating properties of citric acid govern the makeup of the resulting polymer, turning the polymerization system into a rudimentary smart material.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.