Evidence map›Paper›PMID 25990683›Full record

ArticleLung2015

Early Detection of Bi-ventricular and Atrial Mechanical Dysfunction Using Two-Dimensional Speckle Tracking Echocardiography in Patients with Sarcoidosis.

Kursat Tigen, Murat Sunbul, Tansu Karaahmet, Onur Tasar, Cihan Dundar, Murat Yalcinsoy, Mumtaz Takir, Esen Akkaya

Abstract read
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In one paragraph

Article in Lung, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
1.9field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 44 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Clinical and prognostic impact of left atrial strain in non-ischemic cardiomyopathies.The international journal of cardiovascular imaging · 2026
    Review
  6. Catheter ablation of atrial fibrillation in patients with cardiac amyloidosis and sarcoidosis: procedural findings and outcomes.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2025
    Article
  7. Stiff but keeping the beat: catheter ablation for atrial fibrillation in cardiac amyloidosis and sarcoidosis.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2025
    Article
  8. Review
  9. Article
  10. Review
  11. Article
  12. Review
  13. Article
  14. Article
  15. The effect of global longitudinal strain on ımpaired six-minute walk test performance in patients with sarcoidosis.Sarcoidosis, vasculitis, and diffuse lung diseases : official journal of WASOG · 2020
    Article
  16. Article
  17. Article
  18. Article
  19. Diagnostic value of speckle-tracking echocardiography in confirmed cardiac sarcoidosis.Clinical research in cardiology : official journal of the German Cardiac Society · 2016
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 1 country.

Kursat TigenDepartment of Cardiology, Marmara University Faculty of Medicine, Istanbul, Turkey.
Murat SunbulDepartment of Cardiology, Marmara University Faculty of Medicine, Istanbul, Turkey. drsunbul@yahoo.com.tr.
Tansu KaraahmetDepartment of Cardiology, Acibadem University Faculty of Medicine, Istanbul, Turkey.
Onur TasarDepartment of Cardiology, Kartal Kosuyolu Heart Training and Research Hospital, Istanbul, Turkey.
Cihan DundarDepartment of Cardiology, Kartal Kosuyolu Heart Training and Research Hospital, Istanbul, Turkey.
Murat YalcinsoyPulmonary Medicine Clinic, Sureyyapasa Chest Diseases and Thoracic Surgery Training and Research Hospital, Istanbul, Turkey.
Mumtaz TakirDepartment of Endocrinology, Faculty of Medicine, Istanbul Medeniyet University, Istanbul, Turkey.
Esen AkkayaPulmonary Medicine Clinic, Sureyyapasa Chest Diseases and Thoracic Surgery Training and Research Hospital, Istanbul, Turkey.
Kartal Koşuyolu High Specialization Training and Research Hospital · TRMarmara University · TRYedikule Teaching Hospital · TRAcıbadem University · TRIstanbul Medeniyet University · TR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeSarcoidosis is a systemic inflammatory disease with unknown etiology involving several organs. Myocardial involvement, pericarditis, severe rhythm abnormalities, and heart valve disease due to papillary muscle dysfunction are some of the cardiac manifestations. Conventional echocardiographic methods remain insufficient for the determination of subclinical myocardial dysfunction in patients with sarcoidosis. In our study, we investigated the impact of sarcoidosis on bi-ventricular and atrial functions using two-dimensional (2D) speckle tracking echocardiography (STE).

methodsForty patients with sarcoidosis and 20 age and sex-matched controls were recruited into study. All subjects underwent a transthoracic echocardiography for the evaluation of ventricular and atrial functions with 2D STE.

resultsLeft ventricular (LV) dimensions, LV ejection fraction, and right ventricular (RV) systolic velocity were similar between the two groups. Left atrial (LA) diameter was significantly higher in sarcoidosis patients than controls. Eighteen (45%) patients in the sarcoidosis group and 1 (5%) patient in the control group had LV diastolic dysfunction. LV global longitudinal, radial, circumferential strain, twist, untwists, and RV global longitudinal strain values were significantly lower in sarcoidosis patients compared to controls. LA and RA reservoir functions were also significantly lower in sarcoidosis patients than controls.

conclusionAlthough impaired LV diastolic function was detected using conventional parameters, only novel advanced echocardiographic modalities demonstrated impaired bi-ventricular and atrial mechanical functions in patients with sarcoidosis.

Indexed as

Atrial FunctionEarly DiagnosisAdultCase-Control StudiesEchocardiographyFemaleHeart AtriaHumansMaleMiddle AgedOrgan SizeSarcoidosisStroke VolumeVentricular Dysfunction, LeftVentricular Dysfunction, RightAtrial functionSarcoidosisSpeckle tracking echocardiographyVentricular function

Identifiers

PMID25990683
OpenAlexW233189543

What OpenQuestion holds

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Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.