ReviewClinical rheumatology2015
Hypothesis: Human papillomavirus vaccination syndrome--small fiber neuropathy and dysautonomia could be its underlying pathogenesis.
Review in Clinical rheumatology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 43 citations in OpenAlex.
- Severe manifestations of autoimmune syndrome induced by adjuvants (Shoenfeld's syndrome).Immunologic research · 2017Pooled it
- Complex chronic adverse events following immunization: a systemic critique and reform proposal for vaccine pharmacovigilance.Therapeutic advances in drug safety · 2025Article
- Article
- Epidemiology of Upper Limb Complex Regional Pain Syndrome in a Retrospective Cohort of Persons Aged 9-30 Years, 2002-2017.The Permanente journal · 2023Article
- A Case of Autoimmune Small Fiber Neuropathy as Possible Post COVID Sequelae.International journal of environmental research and public health · 2023Article
- Cancer Immunotherapies: What the Perioperative Physician Needs to Know.Current oncology reports · 2022Review
- Novel vaccine safety issues and areas that would benefit from further research.BMJ global health · 2021Review
- Human Papillomavirus Vaccines: An Updated Review.Vaccines · 2020Review
- Human papillomavirus (HPV) vaccine and autonomic disorders: a position statement from the American Autonomic Society.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2020Review
- Autonomic dysfunction and HPV immunization: an overview.Immunologic research · 2018Review
- Vaccine-induced autoimmunity: the role of molecular mimicry and immune crossreaction.Cellular & molecular immunology · 2018Review
- Discrepancies in the evaluation of the safety of the human papillomavirus vaccine.Memorias do Instituto Oswaldo Cruz · 2018Article
- Suspected Adverse Effects After Human Papillomavirus Vaccination: A Temporal Relationship Between Vaccine Administration and the Appearance of Symptoms in Japan.Drug safety · 2017Article
- Serious adverse events after HPV vaccination: a critical review of randomized trials and post-marketing case series.Clinical rheumatology · 2017Review
- Severe somatoform and dysautonomic syndromes after HPV vaccination: case series and review of literature.Immunologic research · 2017Review
- Inadvisable anti-vaccination sentiment: Human Papilloma Virus immunisation falsely under the microscope.NPJ vaccines · 2017Article
- Impact of 2-, 4- and 9-valent HPV vaccines on morbidity and mortality from cervical cancer.Human vaccines & immunotherapeutics · 2016Review
- Re: Proposed HPV vaccination syndrome is unsubstantiated.Clinical rheumatology · 2016Article
- Proposed HPV vaccination syndrome is unsubstantiated.Clinical rheumatology · 2016Article
- HPV vaccines: a controversial issue?Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2016Review
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Vaccination has been one of the most effective public health measures in the history of medicine. However, seemingly inexplicit adverse reactions have been described after the injection of the newer vaccines vs. human papillomavirus (HPV). The symptoms more often reported are chronic pain with paresthesias, headaches, fatigue, and orthostatic intolerance. Adverse reactions appear to be more frequent after HPV vaccination when compared to other type of immunizations. Different isolated cases and small series have described the development of complex regional pain syndrome (CRPS), postural orthostatic tachycardia syndrome (POTS), and fibromyalgia after HPV vaccination. These are illnesses often difficult to diagnose that have overlapping clinical features. Sympathetic nervous system dysfunction seems to play a major role in the pathogenesis of these syndromes. Also, small fiber neuropathy has been recently recognized in CRPS, POTS, and fibromyalgia. This article forwards the hypothesis that small fiber neuropathy and dysautonomia could be the common underlying pathogenesis to the group of rare, but severe reactions that follow HPV vaccination. Clinicians should be aware of the possible association between HPV vaccination and the development of these difficult to diagnose painful dysautonomic syndromes.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.