ArticleLipids in health and disease2015
Poorly controlled cholesterol is associated with cognitive impairment in T2DM: a resting-state fMRI study.
Article in Lipids in health and disease, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 43 citations in OpenAlex.
- Genetic evidence for causal relationships between brain functional networks and domain-specific recovery after nondisabling ischemic stroke.Experimental biology and medicine (Maywood, N.J.) · 2026Article
- Cholesterol-driven pathological astrocytic responses in diabetes-associated cognitive impairment through astrocytic SCAP accumulation and NF-κB-C3 signaling modulation.Experimental & molecular medicine · 2025Article
- Metabolic syndrome is associated with reduced default mode network functional connectivity in young post-9/11 Veterans.Brain imaging and behavior · 2024Article
- Sex Disparity in the Association of Metabolic Syndrome with Cognitive Impairment.Journal of clinical medicine · 2024Article
- Large-scale functional network connectivity mediates the associations between lipids metabolism and cognition in type 2 diabetes.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2024Article
- Bidirectional two-sample mendelian randomization analysis identifies causal associations of MRI-based cortical thickness and surface area relation to NAFLD.Lipids in health and disease · 2024Article
- Impact of sex and serum lipids interaction on working memory: A large-scale brain networks study.Brain and behavior · 2023Article
- Alcohol-induced damage to the fimbria/fornix reduces hippocampal-prefrontal cortex connection during early abstinence.Acta neuropathologica communications · 2023Article
- A Case-Control Study of Cognitive Function in Patients with End-Stage Renal Disease Before and After Hemodialysis in Southern Spain.Medical science monitor : international medical journal of experimental and clinical research · 2023Article
- Quantitative NMR-Based Lipoprotein Analysis Identifies Elevated HDL-4 and Triglycerides in the Serum of Alzheimer's Disease Patients.International journal of molecular sciences · 2022Article
- Inverted U-shaped correlation between serum low-density lipoprotein cholesterol levels and cognitive functions of patients with type 2 diabetes mellitus.Lipids in health and disease · 2021Article
- Association between metabolic syndrome and resting-state functional brain connectivity.Neurobiology of aging · 2021Article
- Large-Scale Internetwork Functional Connectivity Mediates the Relationship between Serum Triglyceride and Working Memory in Young Adulthood.Neural plasticity · 2020Article
- The Application of rs-fMRI in Vascular Cognitive Impairment.Frontiers in neurology · 2020Review
- The CC Genotype ofBioMed research international · 2020Article
- Aberrant patterns of default-mode network functional connectivity associated with metabolic syndrome: A resting-state study.Brain and behavior · 2019Article
- Arthritis and Risk of Cognitive and Functional Impairment in Older Mexican Adults.Journal of aging and health · 2017Article
- Weaker Functional Connectivity Strength in Patients with Type 2 Diabetes Mellitus.Frontiers in neuroscience · 2017Article
- Cerebral Pathology and Cognition in Diabetes: The Merits of Multiparametric Neuroimaging.Frontiers in neuroscience · 2017Review
- Resting-state functional MR imaging shed insights into the brain of diabetes.Metabolic brain disease · 2016Review
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDebate remains on whether hypercholesterolemia is associated with cognitive impairment. Hence, we investigated whether poorly controlled cholesterol impairs functional connectivity among patients with type 2 diabetes mellitus (T2DM).
methodsResting-state functional connectivity infers to an interregional cooperation characterized by synchronous and low-frequency (<0.08 Hz) fluctuations on blood oxygen level-dependent functional magnetic resonance imaging (fMRI). We used resting-state fMRI to investigate the functional connectivity of 25 T2DM patients with poorly controlled cholesterol, 22 patients with target cholesterol and 26 healthy controls. Further correlation analysis was conducted between the functional connectivity and clinical data as well as neuropsychological tests.
resultsThe three groups did not statistically differ in age, sex, education level, body mass index, blood pressure, fasting C-peptides, and triglyceride. Compared with target cholesterol patients, patients with poorly controlled cholesterol showed significantly increased levels of serum cholesterol, low-density lipoprotein (LDL), and LDL/high-density lipoproteins (HDL) ratio, as well as poor performance in Trail Making Test B (TMT-B) (p<0.05). Disordered functional connectivity of bilateral hippocampus-middle frontal gyrus (MFG) in the poorly controlled group consistently existed when compared with the two other groups. Moreover, the aberrant functional connectivity was associated with the TMT-B scores and the LDL/HDL index in T2DM patients with poorly controlled cholesterol.
conclusionsT2DM patients with poorly controlled cholesterol showed impaired attention and executive function. The resting-state connectivity disturbance of the hippocampus-MFG may be involved in this process. Decreasing the LDL/HDL ratio can be taken as precaution against cognitive decrements.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.