Evidence map›Paper›PMID 25989709›Full record

ArticlePaediatric and perinatal epidemiology2015

Birthweight and Childhood Cancer: Preliminary Findings from the International Childhood Cancer Cohort Consortium (I4C).

Ora Paltiel, Gabriella Tikellis, Martha Linet, Jean Golding, Stanley Lemeshow, Gary Phillips, Karen Lamb, Camilla Stoltenberg, Siri E Håberg, Marin Strøm and 10 more

Erratum issuedOpen access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Paediatric and perinatal epidemiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 30 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed, 2 pooled it
8.0field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 2 syntheses or guidelines pooled it, 51 citations in OpenAlex.

  1. Pooled it
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  4. Childhood B cell leukemia: Intercepting the paths to progression.BioEssays : news and reviews in molecular, cellular and developmental biology · 2024
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

20 authors at 16 institutions in 10 countries.

Ora PaltielDepartment of Hematology, Braun School of Public Health, Hadassah-Hebrew University, Jerusalem, Israel.
Gabriella TikellisDepartment of Environmental and Genetic Epidemiology, Murdoch Children's Research Institute, Royal Childrens Hospital, University of Melbourne, Melbourne, Australia.
Martha LinetRadiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, UK.
Jean GoldingCentre for Child & Adolescent Health, School of Social & Community Medicine, University of Bristol, Bristol, UK.
Stanley LemeshowDivision of Biostatistics, College of Public Health, The Ohio State University, Columbus, Ohio, UK.
Gary PhillipsDivision of Biostatistics, The Ohio State University Center for Biostatistics, Columbus, Ohio, UK.
Karen LambCentre for Physical Activity and Nutrition, Deakin University, Burwood, Australia.
Camilla StoltenbergNorwegian Institute of Public Health, Oslo, Norway.
Siri E HåbergNorwegian Institute of Public Health, Oslo, Norway.
Marin StrømDepartment of Epidemiology Research, Center for Fetal Programming, Statenserum Institute, Copenhagen, Denmark.
Charlotta GranstrømDepartment of Epidemiology Research, Center for Fetal Programming, Statenserum Institute, Copenhagen, Denmark.
Kate NorthstoneALSPAC (Children of the 90s), School of Social and Community Medicine, University of Bristol, Bristol, UK.
Mark KlebanoffDivision of Biostatistics, College of Public Health, The Ohio State University, Columbus, Ohio, UK.
Anne-Louise PonsonbyDepartment of Environmental and Genetic Epidemiology, Murdoch Children's Research Institute, Royal Childrens Hospital, University of Melbourne, Melbourne, Australia.
Elizabeth MilneTelethon Kids Institute, University of Western Australia, Perth, Western Australia, Australia.
Marie PedersenCentre for Research in Environmental Epidemiology (CREAL), Barcelona, Spain.
Manolis KogevinasCentre for Research in Environmental Epidemiology (CREAL), Barcelona, Spain.
Eunhee HaSchool of Medicine, Ewha Medical Research Center, Department of Preventive Medicine, Ewha Womans University, Seoul, Korea.
Terence DwyerDepartment of Environmental and Genetic Epidemiology, Murdoch Children's Research Institute, Royal Childrens Hospital, University of Melbourne, Melbourne, Australia; The George Institute for Global Health, University of Oxford, Oxford, UK.
International Childhood Cancer Cohort Consortium
Statens Serum Institut · DKThe Ohio State University · USUniversity of Bristol · GBCentro de Investigación Biomédica en Red de Epidemiología y Salud Pública · ESDeakin University · AUEwha Womans University Medical Center · KRHadassah Medical Center · ILInserm · FRMurdoch Children's Research Institute · AUNational Cancer Institute · USNationwide Children's Hospital · USNorwegian Institute of Public Health · NORoyal Children's Hospital · AUThe University of Western Australia · AUUniversity of Bergen · NOUniversity of Tasmania · AU

Funding

Multidisciplinary Studies of LymphomaZIACP010170 · NCI · DIVISION OF CANCER EPIDEMIOLOGY AND GENETICS · PI MORTON, LINDSAY · 2009 to 2025
$10.7M
Medical Research Council MC_PC_15018Wellcome Trust 092731Wellcome Trust 102215World Health Organization 001
6 · The paper itself

Abstract

backgroundEvidence relating childhood cancer to high birthweight is derived primarily from registry and case-control studies. We aimed to investigate this association, exploring the potential modifying roles of age at diagnosis and maternal anthropometrics, using prospectively collected data from the International Childhood Cancer Cohort Consortium.

methodsWe pooled data on infant and parental characteristics and cancer incidence from six geographically and temporally diverse member cohorts [the Avon Longitudinal Study of Parents and Children (UK), the Collaborative Perinatal Project (USA), the Danish National Birth Cohort (Denmark), the Jerusalem Perinatal Study (Israel), the Norwegian Mother and Child Cohort Study (Norway), and the Tasmanian Infant Health Survey (Australia)]. Birthweight metrics included a continuous measure, deciles, and categories (≥ 4.0 vs. < 4.0 kilogram). Childhood cancer (377 cases diagnosed prior to age 15 years) risk was analysed by type (all sites, leukaemia, acute lymphoblastic leukaemia, and non-leukaemia) and age at diagnosis. We estimated hazard ratios (HR) and 95% confidence intervals (CI) from Cox proportional hazards models stratified by cohort.

resultsA linear relationship was noted for each kilogram increment in birthweight adjusted for gender and gestational age for all cancers [HR = 1.26; 95% CI 1.02, 1.54]. Similar trends were observed for leukaemia. There were no significant interactions with maternal pre-pregnancy overweight or pregnancy weight gain. Birthweight ≥ 4.0 kg was associated with non-leukaemia cancer among children diagnosed at age ≥ 3 years [HR = 1.62; 95% CI 1.06, 2.46], but not at younger ages [HR = 0.7; 95% CI 0.45, 1.24, P for difference = 0.02].

conclusionChildhood cancer incidence rises with increasing birthweight. In older children, cancers other than leukaemia are particularly related to high birthweight. Maternal adiposity, currently widespread, was not demonstrated to substantially modify these associations. Common factors underlying foetal growth and carcinogenesis need to be further explored.

Indexed as

Birth WeightAdolescentAge of OnsetAustraliaChildChild, PreschoolDenmarkFemaleHumansInfantInfant, NewbornIsraelMaleNeoplasmsNorwayOdds RatioChildhood cancercohort studiesleukemiapooled analysis.

Identifiers

PMID25989709
PMCPMC4690513
OpenAlexW1911387651

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.