ArticleScientific reports2015
Genetic association study of circadian genes with seasonal pattern in bipolar disorders.
Article in Scientific reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
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Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it, 56 citations in OpenAlex.
- The genetic overlap between mood disorders and cardiometabolic diseases: a systematic review of genome wide and candidate gene studies.Translational psychiatry · 2017Pooled it
- LncRNACells · 2026Article
- Seasonal metabolic oscillation: adiposity cycling as a candidate amplifier of mood seasonality in seasonal affective and bipolar disorders.Frontiers in psychiatry · 2026Article
- CaMKK2 as an emerging treatment target for bipolar disorder.Molecular psychiatry · 2023Review
- Review
- Circadian Gene Variants in Diseases.Genes · 2023Review
- A Systematic Review on the Impact of Seasonality on Severe Mental Illness Admissions: Does Seasonal Variation Affect Coercion?Healthcare (Basel, Switzerland) · 2023Review
- Does circadian dysrhythmia drive the switch into high- or low-activation states in bipolar I disorder?Bipolar disorders · 2023Review
- Bipolar Chronobiology in Men and Mice: A Narrative Review.Brain sciences · 2023Review
- Cryptochromes in mammals: a magnetoreception misconception?Frontiers in physiology · 2023Review
- Neurobiological and behavioral mechanisms of circadian rhythm disruption in bipolar disorder: A critical multi-disciplinary literature review and agenda for future research from the ISBD task force on chronobiology.Bipolar disorders · 2022Review
- Association between the Arylalkylamine N-Acetyltransferase (AANAT) Gene and Seasonality in Patients with Bipolar Disorder.Psychiatry investigation · 2021Article
- Validity and Usage of the Seasonal Pattern Assessment Questionnaire (SPAQ) in a French Population of Patients with Depression, Bipolar Disorders and Controls.Journal of clinical medicine · 2021Article
- Converging evidence that short-active photoperiod increases acetylcholine signaling in the hippocampus.Cognitive, affective & behavioral neuroscience · 2020Article
- Sensitivity to Climate and Weather Changes in Euthymic Bipolar Subjects: Association With Suicide Attempts.Frontiers in psychiatry · 2020Article
- Loss of RAR-related orphan receptor alpha (RORα) selectively lowers docosahexaenoic acid in developing cerebellum.Prostaglandins, leukotrienes, and essential fatty acids · 2020Article
- Mice with reduced DAT levels recreate seasonal-induced switching between states in bipolar disorder.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2018Article
- Evaluation of the Association Between Genetic Variants in Circadian Rhythm Genes and Posttraumatic Stress Symptoms Identifies a Potential Functional Allele in the Transcription FactorFrontiers in psychiatry · 2018Article
- Disruption of melatonin synthesis is associated with impaired 14-3-3 and miR-451 levels in patients with autism spectrum disorders.Scientific reports · 2017Article
- Layer-specific chromatin accessibility landscapes reveal regulatory networks in adult mouse visual cortex.eLife · 2017Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
About one fourth of patients with bipolar disorders (BD) have depressive episodes with a seasonal pattern (SP) coupled to a more severe disease. However, the underlying genetic influence on a SP in BD remains to be identified. We studied 269 BD Caucasian patients, with and without SP, recruited from university-affiliated psychiatric departments in France and performed a genetic single-marker analysis followed by a gene-based analysis on 349 single nucleotide polymorphisms (SNPs) spanning 21 circadian genes and 3 melatonin pathway genes. A SP in BD was nominally associated with 14 SNPs identified in 6 circadian genes: NPAS2, CRY2, ARNTL, ARNTL2, RORA and RORB. After correcting for multiple testing, using a false discovery rate approach, the associations remained significant for 5 SNPs in NPAS2 (chromosome 2:100793045-100989719): rs6738097 (pc = 0.006), rs12622050 (pc = 0.006), rs2305159 (pc = 0.01), rs1542179 (pc = 0.01), and rs1562313 (pc = 0.02). The gene-based analysis of the 349 SNPs showed that rs6738097 (NPAS2) and rs1554338 (CRY2) were significantly associated with the SP phenotype (respective Empirical p-values of 0.0003 and 0.005). The associations remained significant for rs6738097 (NPAS2) after Bonferroni correction. The epistasis analysis between rs6738097 (NPAS2) and rs1554338 (CRY2) suggested an additive effect. Genetic variations in NPAS2 might be a biomarker for a seasonal pattern in BD.
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