Evidence map›Paper›PMID 25988841›Full record

ArticleScientific reports2015

Application of high-dimensional feature selection: evaluation for genomic prediction in man.

M L Bermingham, R Pong-Wong, A Spiliopoulou, C Hayward, I Rudan, H Campbell, A F Wright, J F Wilson, F Agakov, P Navarro and 1 more

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 85 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
85citing papers in PubMed, 1 pooled it
22.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

85 citing papers in PubMed, 1 synthesis or guideline pooled it, 331 citations in OpenAlex.

  1. Pooled it
  2. Review
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  18. Machine learning for microbiologists.Nature reviews. Microbiology · 2024
    Review
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  20. Article

25 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

M L BerminghamMRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh.
R Pong-WongThe Roslin Institute and Royal (Dick) School of Veterinary Studies, University of Edinburgh.
A SpiliopoulouMRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh.
C HaywardMRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh.
I RudanCentre for Population Health Sciences, University of Edinburgh.
H CampbellCentre for Population Health Sciences, University of Edinburgh.
A F WrightMRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh.
J F WilsonCentre for Population Health Sciences, University of Edinburgh.
F AgakovPharmatics Limited, UK.
P NavarroMRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh.
C S Haley1] MRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh [2] The Roslin Institute and Royal (Dick) School of Veterinary Studies, University of Edinburgh.
MRC Institute of Genetics and Molecular Medicine · GBUniversity of Edinburgh · GB4D Pharma (United Kingdom) · GB

Funding

Biotechnology and Biological Sciences Research Council BB/I014144/1Chief Scientist Office CZB/4/276Chief Scientist Office CZB/4/438Chief Scientist Office CZB/4/710Medical Research Council MC_PC_U127561128Medical Research Council MC_PC_U127592696
6 · The paper itself

Abstract

In this study, we investigated the effect of five feature selection approaches on the performance of a mixed model (G-BLUP) and a Bayesian (Bayes C) prediction method. We predicted height, high density lipoprotein cholesterol (HDL) and body mass index (BMI) within 2,186 Croatian and into 810 UK individuals using genome-wide SNP data. Using all SNP information Bayes C and G-BLUP had similar predictive performance across all traits within the Croatian data, and for the highly polygenic traits height and BMI when predicting into the UK data. Bayes C outperformed G-BLUP in the prediction of HDL, which is influenced by loci of moderate size, in the UK data. Supervised feature selection of a SNP subset in the G-BLUP framework provided a flexible, generalisable and computationally efficient alternative to Bayes C; but careful evaluation of predictive performance is required when supervised feature selection has been used.

Indexed as

Body Mass IndexQuantitative Trait, HeritableBayes TheoremBody HeightCholesterol, HDLGenomicsHumansModels, GeneticPhenotypePolymorphism, Single NucleotideQuantitative Trait LociCholesterol, HDL

Identifiers

PMID25988841
PMCPMC4437376
OpenAlexW2163891305

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.