Evidence map›Paper›PMID 25988660›Full record

ReviewBone2015

Trabecular bone score (TBS) as a new complementary approach for osteoporosis evaluation in clinical practice.

N C Harvey, C C Glüer, N Binkley, E V McCloskey, M-L Brandi, C Cooper, D Kendler, O Lamy, A Laslop, B M Camargos and 3 more

Registry-linked trialOpen access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Bone, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06860581 (The Impact of Dietary Supplementation With Lactobacillus Helveticus and Bifidobacterium Longum on the Functioning of the Brain-gut Axis, in the Context of Mental Health, Eating Patterns and Nutritional Status of Young Adults), which is not on this map. Cited by 214 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
214citing papers in PubMed, 7 pooled it
37.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06860581 nacompletednot on this mapstarted 2023, after this paper: background citation

The Impact of Dietary Supplementation With Lactobacillus Helveticus and Bifidobacterium Longum on the Functioning of the Brain-gut Axis, in the Context of Mental Health, Eating Patterns and Nutritional Status of Young Adults

TypeinterventionalSponsorPoznan University of Life SciencesRan2023 to 2024Enrolled120ConditionsHealthy Volunteers, Young Adult, WomenArmsIntervention (Sanprobi®Stress), Placebo
3 · Its place in the literature

Who cites it

214 citing papers in PubMed, 7 syntheses or guidelines pooled it, 466 citations in OpenAlex.

  1. Guideline
  2. Guideline
  3. Trabecular bone score in adults with type 1 diabetes: a meta-analysis.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2024
    Pooled it
  4. Previous fracture and subsequent fracture risk: a meta-analysis to update FRAX.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2023
    Pooled it
  5. Pooled it
  6. Pooled it
  7. European guidance for the diagnosis and management of osteoporosis in postmenopausal women.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2019
    Guideline
  8. Trial
  9. Trial
  10. Denosumab After Teriparatide in Premenopausal Women With Idiopathic Osteoporosis.The Journal of clinical endocrinology and metabolism · 2022
    Trial
  11. Trial
  12. Trial
  13. Trial
  14. The effect of metformin versus placebo in combination with insulin analogues on bone mineral density and trabecular bone score in patients with type 2 diabetes mellitus: a randomized placebo-controlled trial.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2018
    Trial
  15. Abaloparatide-SC improves trabecular microarchitecture as assessed by trabecular bone score (TBS): a 24-week randomized clinical trial.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2018
    Trial
  16. Effect of denosumab on trabecular bone score in postmenopausal women with osteoporosis.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2017
    Trial
  17. Article
  18. Review
  19. Management of glucocorticoid-induced osteoporosis in rheumatic diseases.Best practice & research. Clinical rheumatology · 2026
    Review
  20. Article

154 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 9 institutions in 8 countries.

N C HarveyMRC Lifecourse Epidemiology Unit, University of Southampton, Southampton, UK; NIHR Southampton Nutrition Biomedical Research Centre, University of Southampton and University Hospital Southampton NHS Foundation Trust, Southampton, UK. Electronic address: nch@mrc.soton.ac.uk.
C C GlüerSektion Biomedizinische Bildgebung, Klinik für Radiologie und Neuroradiologie, Universitätsklinikum Schleswig-Holstein, Campus Kiel, Kiel, Germany.
N BinkleyOsteoporosis Clinical Research Program, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.
E V McCloskeyCentre for Metabolic Bone Diseases, University of Sheffield, Sheffield, UK.
M-L BrandiDepartment of Surgery and Translational Medicine, University of Florence, Florence, Italy.
C CooperMRC Lifecourse Epidemiology Unit, University of Southampton, Southampton, UK; NIHR Southampton Nutrition Biomedical Research Centre, University of Southampton and University Hospital Southampton NHS Foundation Trust, Southampton, UK; NIHR Musculoskeletal Biomedical Research Unit, University of Oxford, Oxford, UK.
D KendlerDepartment of Medicine, University of British Columbia, Vancouver, Canada.
O LamyBone Unit, University Hospital, Lausanne, Switzerland.
A LaslopScientific Office, Austrian Agency for Health and Food Safety, Vienna, Austria.
B M CamargosUnidade de Densitometria Óssea, Densimater Rede Materdei de Saúde, Belo Horizonte, MG, Brazil.
J-Y ReginsterDepartment of Public Health, Epidemiology and Health Economics, University of Liege, Liege, Belgium.
R RizzoliService of Bone Diseases, Geneva University Hospitals and Faculty of Medicine, Geneva, Switzerland.
J A KanisCentre for Metabolic Bone Diseases, University of Sheffield, Sheffield, UK. Electronic address: w.j.pontefract@sheffield.ac.uk.
MRC Lifecourse Epidemiology Unit · GBUniversity of Sheffield · GBAustrian Agency for Health and Food Safety · ATUniversity Hospital of Geneva · CHUniversity of British Columbia · CAUniversity of Florence · ITUniversity of Liège · BEUniversity of Lübeck · DEUniversity of Wisconsin–Madison · US

Funding

Arthritis Research UK 17702Department of Health HTA/10/33/04Medical Research Council G0400491Medical Research Council MC_U147585819Medical Research Council MC_U147585824Medical Research Council MC_U147585827Medical Research Council MC_UP_A620_1014Medical Research Council MC_UU_12011/1Medical Research Council MR/K006312/1
6 · The paper itself

Abstract

Trabecular bone score (TBS) is a recently-developed analytical tool that performs novel grey-level texture measurements on lumbar spine dual X-ray absorptiometry (DXA) images, and thereby captures information relating to trabecular microarchitecture. In order for TBS to usefully add to bone mineral density (BMD) and clinical risk factors in osteoporosis risk stratification, it must be independently associated with fracture risk, readily obtainable, and ideally, present a risk which is amenable to osteoporosis treatment. This paper summarizes a review of the scientific literature performed by a Working Group of the European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis. Low TBS is consistently associated with an increase in both prevalent and incident fractures that is partly independent of both clinical risk factors and areal BMD (aBMD) at the lumbar spine and proximal femur. More recently, TBS has been shown to have predictive value for fracture independent of fracture probabilities using the FRAX® algorithm. Although TBS changes with osteoporosis treatment, the magnitude is less than that of aBMD of the spine, and it is not clear how change in TBS relates to fracture risk reduction. TBS may also have a role in the assessment of fracture risk in some causes of secondary osteoporosis (e.g., diabetes, hyperparathyroidism and glucocorticoid-induced osteoporosis). In conclusion, there is a role for TBS in fracture risk assessment in combination with both aBMD and FRAX.

Indexed as

Absorptiometry, PhotonAdultAgedAlgorithmsBone and BonesBone DensityCross-Sectional StudiesCushing SyndromeDiabetes Mellitus, Type 2FemaleFemurFracture HealingHumansHyperparathyroidism, PrimaryLumbar VertebraeMaleBone mineral densityEpidemiologyFragility fractureFRAXOsteoporosisTrabecular bone score (TBS)

Identifiers

PMID25988660
PMCPMC4538791
OpenAlexW1939179845

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.