ArticleVector borne and zoonotic diseases (Larchmont, N.Y.)2015
Single-Nucleotide Polymorphisms Reveal Spatial Diversity Among Clones of Yersinia pestis During Plague Outbreaks in Colorado and the Western United States.
Article in Vector borne and zoonotic diseases (Larchmont, N.Y.), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
14 citing papers in PubMed, 27 citations in OpenAlex.
- Edible baits for systemic flea control, plague mitigation, and wildlife conservation: evaluation of four active ingredients with three rodent species in western North America.International journal for parasitology. Parasites and wildlife · 2026Article
- Prairie dog responses to vector control and vaccination during an initialInternational journal for parasitology. Parasites and wildlife · 2024Article
- Article
- Polygenic plague resistance in the great gerbil uncovered by population sequencing.PNAS nexus · 2022Article
- Plague risk in the western United States over seven decades of environmental change.Global change biology · 2022Article
- Assembling a safe and effective toolbox for integrated flea control and plague mitigation: Fipronil experiments with prairie dogs.PloS one · 2022Article
- Exploring and Mitigating Plague for One Health Purposes.Current tropical medicine reports · 2022Article
- Oral Sylvatic Plague Vaccine Does Not Adequately Protect Prairie Dogs (Vector borne and zoonotic diseases (Larchmont, N.Y.) · 2021Article
- Plague transforms positive effects of precipitation on prairie dogs to negative effects.International journal for parasitology. Parasites and wildlife · 2021Article
- Differential plague susceptibility in species and populations of prairie dogs.Ecology and evolution · 2019Article
- Prairie Dogs, Persistent Plague, Flocking Fleas, and Pernicious Positive Feedback.Frontiers in veterinary science · 2019Article
- Yersinia pestis Survival and Replication in Potential Ameba Reservoir.Emerging infectious diseases · 2018Article
- Investigation of and Response to 2 Plague Cases, Yosemite National Park, California, USA, 2015.Emerging infectious diseases · 2016Article
- Article
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIn western North America, plague epizootics caused by Yersinia pestis appear to sweep across landscapes, primarily infecting and killing rodents, especially ground squirrels and prairie dogs. During these epizootics, the risk of Y. pestis transmission to humans is highest. While empirical models that include climatic conditions and densities of rodent hosts and fleas can predict when epizootics are triggered, bacterial transmission patterns across landscapes, and the scale at which Y. pestis is maintained in nature during inter-epizootic periods, are poorly defined. Elucidating the spatial extent of Y. pestis clones during epizootics can determine whether bacteria are propagated across landscapes or arise independently from local inter-epizootic maintenance reservoirs. MATERIAL AND
methodsWe used DNA microarray technology to identify single-nucleotide polymorphisms (SNPs) in 34 Y. pestis isolates collected in the western United States from 1980 to 2006, 21 of which were collected during plague epizootics in Colorado. Phylogenetic comparisons were used to elucidate the hypothesized spread of Y. pestis between the mountainous Front Range and the eastern plains of northern Colorado during epizootics. Isolates collected from across the western United States were included for regional comparisons.
resultsBy identifying SNPs that mark individual clones, our results strongly suggest that Y. pestis is maintained locally and that widespread epizootic activity is caused by multiple clones arising independently at small geographic scales. This is in contrast to propagation of individual clones being transported widely across landscapes. Regionally, our data are consistent with the notion that Y. pestis diversifies at relatively local scales following long-range translocation events. We recommend that surveillance and prediction by public health and wildlife management professionals focus more on models of local or regional weather patterns and ecological factors that may increase risk of widespread epizootics, rather than predicting or attempting to explain epizootics on the basis of movement of host species that may transport plague.
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