Evidence map›Paper›PMID 25988365›Full record

Trial reportBehaviour research and therapy2015

Bothersome tics in patients with chronic tic disorders: Characteristics and individualized treatment response to behavior therapy.

Joseph F McGuire, John Piacentini, Lawrence Scahill, Douglas W Woods, Robert Villarreal, Sabine Wilhelm, John T Walkup, Alan L Peterson

2 registry-linked trialsAbstract readRandomized Controlled Trial
In one paragraph

Trial report in Behaviour research and therapy, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 22 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 2 pooled it
6.8field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00218777 phase2 / phase3completednot on this map

Behavior Therapy for Children With Chronic Tic Disorders

TypeinterventionalSponsorTourette Association of AmericaRan2004 to 2007Enrolled120ConditionsTourette Syndrome, Tic DisordersArmsComprehensive Behavioral Intervention for Tics
NCT00231985 phase2completednot on this map

Behavior Therapy and Psychosocial Treatment for Tourette Syndrome and Chronic Tic Disorder

TypeinterventionalSponsorMassachusetts General HospitalRan2005 to 2010Enrolled122ConditionsTourette Syndrome, Tic DisordersArmsHabit reversal therapy, Supportive therapy
3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 2 syntheses or guidelines pooled it, 69 citations in OpenAlex.

  1. Pooled it
  2. Guideline
  3. Trial
  4. Trial
  5. Article
  6. Article
  7. Evidence-Based Behavior Therapy for Tourette Syndrome.The Psychiatric clinics of North America · 2025
    Review
  8. Article
  9. Automated Quantification of Eye Tics Using Computer Vision and Deep Learning Techniques.Movement disorders : official journal of the Movement Disorder Society · 2024
    Article
  10. Article
  11. Review
  12. Article
  13. Review
  14. Article
  15. Article
  16. Review
  17. Article
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 7 institutions in 1 country.

Joseph F McGuireSemel Institute of Neuroscience and Human Behavior, University of California Los Angeles, 760 Westwood Plaza, Los Angeles, CA 90095, USA. Electronic address: jfmcguire@mednet.ucla.edu.
John PiacentiniSemel Institute of Neuroscience and Human Behavior, University of California Los Angeles, 760 Westwood Plaza, Los Angeles, CA 90095, USA. Electronic address: jpiacentini@mednet.ucla.edu.
Lawrence ScahillMarcus Center, Emory University School of Medicine, 1920 Briarcliff Rd NE, Atlanta, GA 30329, USA. Electronic address: lawrence.scahill@emory.edu.
Douglas W WoodsDepartment of Psychology, University of Texas A&M, 4235 TAMU, College Station, TX 77843, USA. Electronic address: dowoods@tamu.edu.
Robert VillarrealDepartment of Psychiatry, University of Texas Health Science Center at San Antonio, 7550 IH 10 West, Suite 1325, San Antonio, TX 78229, USA. Electronic address: villarrear10@uthscsa.edu.
Sabine WilhelmMassachusetts General Hospital and Harvard Medical School, 185 Cambridge St., Suite 2000, Boston, MA 02114, USA. Electronic address: swilhelm@mgh.harvard.edu.
John T WalkupWeil Cornell Medical College, Cornell University, 525 E. 68th St., New York, NY 10065, USA. Electronic address: jtw9001@med.cornell.edu.
Alan L PetersonDepartment of Psychiatry, University of Texas Health Science Center at San Antonio, 7550 IH 10 West, Suite 1325, San Antonio, TX 78229, USA; South Texas Veterans Health Care System, 7400 Merton Minter Boulevard, San Antonio, TX 78229, USA; University of Texas at San Antonio, One UTSA Circle, San Antonio, TX 78249, USA. Electronic address: petersona3@uthscsa.edu.
University of California, Los Angeles · USCornell University · USEmory University · USMassachusetts General Hospital · USSouth Texas Veterans Health Care System · USTexas A&M University · USThe University of Texas Health Science Center at San Antonio · US

Funding

Behavior Therapy for Children with Chronic Tic DisordersR01MH070802 · NIMH · TOURETTE SYNDROME ASSOCIATION, INC · PI PIACENTINI, JOHN C. · 2004 to 2007
$2.9M
Behavior Therapy for Adults with Tourette SyndromeR01MH069874 · NIMH · YALE UNIVERSITY · PI SCAHILL, LAWRENCE D. · 2005 to 2009
$1.2M
Behavior Therapy for Adults with Tourette SyndromeR01MH069877 · NIMH · MASSACHUSETTS GENERAL HOSPITAL · PI WILHELM, SABINE · 2005 to 2009
$918k
Behavior Therapy for Adults with Tourette SyndromeR01MH069875 · NIMH · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI PETERSON, ALAN L · 2005 to 2008
$719k
NIMH NIH HHS 5R01MH069877NIMH NIH HHS R01 MH069874NIMH NIH HHS R01MH069874NIMH NIH HHS R01 MH069875NIMH NIH HHS R01MH069875NIMH NIH HHS R01 MH069877NIMH NIH HHS R01 MH070802NIMH NIH HHS R01MH070802
6 · The paper itself

Abstract

This report examined the most frequently reported bothersome tics among individuals with chronic tic disorders and evaluated the improvement and remission of tics and their associated characteristics. Youths and adults (N = 240) were randomly assigned to receive the comprehensive behavioral intervention for tics (CBIT) or psychoeducation and supportive therapy (PST). At baseline, motor tics and tics with an urge were rated as more bothersome relative to vocal tics and tics without premonitory urges. The five most common bothersome tics included eye blinking, head jerks, sniffing, throat clearing, and other complex motor tics. While CBIT outperformed PST across tic type and urge presence, tics preceded by premonitory urges at baseline had higher severity at posttreatment across treatment condition. Six individual tic types had lower severity at posttreatment following CBIT relative to PST. Baseline urge presence was associated with tic remission for CBIT but not PST. Specific bothersome tics were more likely to remit with CBIT relative to PST. Findings suggest that individual tics respond and remit differently to CBIT relative to PST, with implications highlighting the negative reinforcement hypothesis in tic symptom maintenance. CLINICALTRIALS. GOV IDENTIFIERS: NCT00218777; NCT00231985.

Indexed as

AdolescentAdultAgedBehavior TherapyChildFemaleHumansMaleMiddle AgedSeverity of Illness IndexTic DisordersTicsTreatment OutcomeYoung AdultBehavior therapyComprehensive behavioral intervention for ticsHabit reversal trainingIndividualized treatment responseTourette's disorderTreatment outcome

Identifiers

PMID25988365
PMCPMC4449823
OpenAlexW227349039

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.