ArticleFrontiers in molecular biosciences2015
Elements of the cellular metabolic structure.
Article in Frontiers in molecular biosciences, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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22 citing papers in PubMed, 53 citations in OpenAlex.
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- From representations to servomechanisms to oscillators: my journey in the study of cognition.Animal cognition · 2023Review
- Reactive Oxygen, Nitrogen, and Sulfur Species (RONSS) as a Metabolic Cluster for Signaling and Biostimulation of Plants: An Overview.Plants (Basel, Switzerland) · 2022Review
- Metabolomics-Driven Mining of Metabolite Resources: Applications and Prospects for Improving Vegetable Crops.International journal of molecular sciences · 2022Review
- Bodily memory in slime mold.Learning & behavior · 2022Article
- Oscillators and servomechanisms in orientation and navigation, and sometimes in cognition.Proceedings. Biological sciences · 2022Review
- Self-Organization and Information Processing: From Basic Enzymatic Activities to Complex Adaptive Cellular Behavior.Frontiers in genetics · 2021Review
- Associative Conditioning Is a Robust Systemic Behavior in Unicellular Organisms: An Interspecies Comparison.Frontiers in microbiology · 2021Article
- Cell Motility and Cancer.Cancers · 2020Review
- Plants are intelligent, here's how.Annals of botany · 2020Article
- The nucleus does not significantly affect the migratory trajectories of amoeba in two-dimensional environments.Scientific reports · 2019Article
- Evidence of conditioned behavior in amoebae.Nature communications · 2019Article
- Incomplete Healing as a Cause of Aging: The Role of Mitochondria and the Cell Danger Response.Biology · 2019Review
- Review
- Multisite tumor sampling enhances the detection of intratumor heterogeneity at all different temporal stages of tumor evolution.Virchows Archiv : an international journal of pathology · 2018Article
- Dynamic properties of calcium-activated chloride currents in Xenopus laevis oocytes.Scientific reports · 2017Article
- Detection of Intratumor Heterogeneity in Modern Pathology: A Multisite Tumor Sampling Perspective.Frontiers in medicine · 2017Article
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A large number of studies have demonstrated the existence of metabolic covalent modifications in different molecular structures, which are able to store biochemical information that is not encoded by DNA. Some of these covalent mark patterns can be transmitted across generations (epigenetic changes). Recently, the emergence of Hopfield-like attractor dynamics has been observed in self-organized enzymatic networks, which have the capacity to store functional catalytic patterns that can be correctly recovered by specific input stimuli. Hopfield-like metabolic dynamics are stable and can be maintained as a long-term biochemical memory. In addition, specific molecular information can be transferred from the functional dynamics of the metabolic networks to the enzymatic activity involved in covalent post-translational modulation, so that determined functional memory can be embedded in multiple stable molecular marks. The metabolic dynamics governed by Hopfield-type attractors (functional processes), as well as the enzymatic covalent modifications of specific molecules (structural dynamic processes) seem to represent the two stages of the dynamical memory of cellular metabolism (metabolic memory). Epigenetic processes appear to be the structural manifestation of this cellular metabolic memory. Here, a new framework for molecular information storage in the cell is presented, which is characterized by two functionally and molecularly interrelated systems: a dynamic, flexible and adaptive system (metabolic memory) and an essentially conservative system (genetic memory). The molecular information of both systems seems to coordinate the physiological development of the whole cell.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.