ReviewFrontiers in nutrition2014
Rheumatoid cachexia revisited: a metabolic co-morbidity in rheumatoid arthritis.
Review in Frontiers in nutrition, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06400316 (Preventing Muscle Wasting During Rheumatoid Arthritis Flares), which is not on this map. Cited by 50 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Preventing Muscle Wasting During Rheumatoid Arthritis Flares: A Randomised Controlled Trial
Who cites it
50 citing papers in PubMed, 1 synthesis or guideline pooled it, 78 citations in OpenAlex.
- Prevalence of rheumatoid cachexia in rheumatoid arthritis: a systematic review and meta-analysis.Journal of cachexia, sarcopenia and muscle · 2018Pooled it
- Levels of the Novel Endogenous Antagonist of Ghrelin Receptor, Liver-Enriched Antimicrobial Peptide-2, in Patients with Rheumatoid Arthritis.Nutrients · 2020Trial
- Article
- Zaleya pentandra L. produces anti-arthritic effects by downregulating IL-6, NF-κB, and TNF-α and mitigating oxidative stress.Inflammopharmacology · 2026Article
- Association Between Prognostic Nutritional Index and Disease Activity in Patients with Rheumatoid Arthritis: A Retrospective Cohort Study.Mediterranean journal of rheumatology · 2026Article
- Loss of Lean Mass in Rheumatoid Arthritis Is Associated With Loss of Total and Visceral Fat.Journal of cachexia, sarcopenia and muscle · 2026Article
- Observational
- Role of Myostatin in Rheumatoid Arthritis: A Review of the Clinical Impact.Diagnostics (Basel, Switzerland) · 2024Review
- From amino-acid to disease: the effects of oxidation on actin-myosin interactions in muscle.Journal of muscle research and cell motility · 2023Review
- Effect of Filgotinib on Body Mass Index (BMI) and Effect of Baseline BMI on the Efficacy and Safety of Filgotinib in Rheumatoid Arthritis.Rheumatology and therapy · 2023Article
- Effects of Exercise on Body Composition and Physical Function in Rheumatoid Arthritis Patients: Scoping Review.Open access rheumatology : research and reviews · 2023Article
- Risk Factors of Muscle Wasting in Women with Rheumatoid Arthritis: Relevance of the Persistent Failure of Conventional Combination Therapy.Healthcare (Basel, Switzerland) · 2022Article
- Time to Deal with Rheumatoid Cachexia: Prevalence, Diagnostic Criteria, Treatment Effects and Evidence for Management.Mediterranean journal of rheumatology · 2022Review
- Demographic, Lifestyle, and Serologic Risk Factors for Rheumatoid Arthritis (RA)-associated Bronchiectasis: Role of RA-related Autoantibodies.The Journal of rheumatology · 2022Article
- Nerolidol: a potential approach in rheumatoid arthritis through reduction of TNF-α, IL-1β, IL-6, NF-kB, COX-2 and antioxidant effect in CFA-induced arthritic model.Inflammopharmacology · 2022Article
- Hip BMD is associated with visceral fat change: a registry study of osteoporosis and sarcopenia.Therapeutic advances in chronic disease · 2022Article
- Evaluation of the mechanisms of sarcopenia in chronic inflammatory disease: protocol for a prospective cohort study.Skeletal muscle · 2021Article
- Ameliorating Effects of Coriander on Gastrocnemius Muscles Undergoing Precachexia in a Rat Model of Rheumatoid Arthritis: A Proteomics Analysis.Nutrients · 2021Article
- Unresolved intramuscular inflammation, not diminished skeletal muscle regenerative capacity, is at the root of rheumatoid cachexia: insights from a rat CIA model.Physiological reports · 2021Article
- Autoimmune Rheumatic Diseases and Vascular Function: The Concept of Autoimmune Atherosclerosis.Journal of clinical medicine · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Rheumatoid arthritis (RA) is a chronic inflammatory disease in which pro-inflammatory cytokines, including tumor necrosis factor (TNF)-α, play a crucial role. The chronic inflammation, combined with reduced physical activity, leads to muscle wasting whereas fat mass would be maintained; the resulting abnormal metabolic state is described as rheumatoid cachexia. Since the loss of muscle volume would be compensated by the increased fat mass, body mass index (BMI) is reported not to reflect the nutritional status in RA patients. The implication of rheumatoid cachexia for cardiovascular risk and clinical prognosis is not clearly understood, however, adequate control of disease activity in combination with appropriate physical exercise could be the most important strategy to control rheumatoid cachexia and related metabolic problems.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.