ReviewFrontiers in nutrition2014
Zinc is an Antioxidant and Anti-Inflammatory Agent: Its Role in Human Health.
Review in Frontiers in nutrition, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 185 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Relationship of Whole Blood Zinc Levels to Acne Severity Among Filipinos 18-25 Years Old: A Cross-sectional Comparative Study
A Randomized, Double Blind, Placebo-Controlled Clinical Trial of the Effects of Oral Zinc Gluconate Among Diagnosed Acne Vulgaris Patients
Who cites it
185 citing papers in PubMed, 5 syntheses or guidelines pooled it.
- Systematic Review and Meta-Analysis: Association Between Circulating and Tissue Levels of Selenium and Zinc and Breast Cancer Risk.The breast journal · 2026Pooled it
- Procalcitonin and biomarkers for stroke-associated pneumonia: a systematic review and meta-analysis.BMC pulmonary medicine · 2025Pooled it
- The Dual Edge of zinc: linking excessive intake to obesity, diabetes, hypertension, and cardiovascular risks.Acta biochimica Polonica · 2025Pooled it
- The Prognostic Value of Serum Zinc Levels in Acutely Hospitalized Patients: a Systematic Review.Biological trace element research · 2021Pooled it
- Oral zinc for treating diarrhoea in children.The Cochrane database of systematic reviews · 2016Pooled it
- Co-supplementation of zinc and probiotic on oxidative stress markers and sleep quality index in irritable bowel syndrome patients: a double-blind randomized controlled trial.European journal of nutrition · 2026Trial
- Zinc Supplementation, Inflammation, and Gut Integrity Markers in HIV Infection: A Randomized Placebo-Controlled Trial.Nutrients · 2025Trial
- Effects of Zinc Supplementation on Inflammatory and Cognitive Parameters in Middle-Aged Women with Overweight or Obesity.Nutrients · 2023Trial
- Trial
- The Effects of Zinc Sulfate Supplementation on Serum Copeptin, C-Reactive Protein and Metabolic Markers in Zinc-Deficient Diabetic Patients on Hemodialysis: A Randomized, Double-Blind, Placebo-Controlled Trial.Biological trace element research · 2022Trial
- Changes in nutrient intake and inflammation following an anti-inflammatory diet in spinal cord injury.The journal of spinal cord medicine · 2019Trial
- Markers of Systemic Inflammation and Environmental Enteric Dysfunction Are Not Reduced by Zinc or Multivitamins in Tanzanian Infants: A Randomized, Placebo-Controlled Trial.The Journal of pediatrics · 2019Trial
- A moderate increase in dietary zinc reduces DNA strand breaks in leukocytes and alters plasma proteins without changing plasma zinc concentrations.The American journal of clinical nutrition · 2017Trial
- Multifunctional hydrogel scaffolds for endogenous osteochondral regeneration.Regenerative therapy · 2026Review
- Bioinspired zinc-doped carbon dots protect against polystyrene microplastic-induced spermatogenic dysfunction through Nrf2 activation and cuproptosis suppression.Materials today. Bio · 2026Article
- Protective effects of zinc against testicular dysfunction, oxidative stress, and disturbances in biochemical, molecular, and tissue structure induced by hexavalent chromium.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2026Article
- Dose-response associations of the composite dietary antioxidant index and related nutrients with prevalent chronic kidney disease: NHANES 2003-2018.BMC nephrology · 2026Article
- Zinc alleviates arsenic-induced muscle injury in common carp through modulation of oxidative stress and related signaling pathways.Fish physiology and biochemistry · 2026Article
- Ion sequential therapy aligned with pathological changes enhances cardiac function after myocardial infarction.Cell reports. Medicine · 2026Article
- Article
125 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Zinc supplementation trials in the elderly showed that the incidence of infections was decreased by approximately 66% in the zinc group. Zinc supplementation also decreased oxidative stress biomarkers and decreased inflammatory cytokines in the elderly. In our studies in the experimental model of zinc deficiency in humans, we showed that zinc deficiency per se increased the generation of IL-1β and its mRNA in human mononuclear cells following LPS stimulation. Zinc supplementation upregulated A20, a zinc transcription factor, which inhibited the activation of NF-κB, resulting in decreased generation of inflammatory cytokines. Oxidative stress and chronic inflammation are important contributing factors for several chronic diseases attributed to aging, such as atherosclerosis and related cardiac disorders, cancer, neurodegeneration, immunologic disorders and the aging process itself. Zinc is very effective in decreasing reactive oxygen species (ROS). In this review, the mechanism of zinc actions on oxidative stress and generation of inflammatory cytokines and its impact on health in humans will be presented.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.