Evidence map›Paper›PMID 25987957›Full record

ReviewWorld journal of diabetes2015

Type 2 diabetes mellitus: From a metabolic disorder to an inflammatory condition.

Iqra Hameed, Shariq R Masoodi, Shahnaz A Mir, Mudasar Nabi, Khalid Ghazanfar, Bashir A Ganai

Registry-linked trialOpen access · diamondAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in World journal of diabetes, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06322212 (Type 2 Diabetes Mellitus and Blood Brain Barrier Improvement - A Randomized Clinical Trial), which is not on this map. Cited by 230 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
230citing papers in PubMed, 4 pooled it
17.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06322212 early_phase1recruitingnot on this mapstarted 2024, after this paper: background citation

Type 2 Diabetes Mellitus and Blood Brain Barrier Improvement - A Randomized Clinical Trial

TypeinterventionalSponsorUniversity of California, Los AngelesRan2024 to 2027Enrolled52ConditionsType2diabetesArmsThiamine, Placebo
3 · Its place in the literature

Who cites it

230 citing papers in PubMed, 4 syntheses or guidelines pooled it, 487 citations in OpenAlex.

  1. Pooled it
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  4. Comorbidities and the risk of severe or fatal outcomes associated with coronavirus disease 2019: A systematic review and meta-analysis.International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 2020
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  10. Potential of anthocyanin as an anti-inflammatory agent: a human clinical trial on type 2 diabetic, diabetic at-risk and healthy adults.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2021
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170 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Iqra HameedIqra Hameed, Mudasar Nabi, Khalid Ghazanfar, Department of Biochemistry, University of Kashmir, Srinagar 190006, India.
Shariq R MasoodiIqra Hameed, Mudasar Nabi, Khalid Ghazanfar, Department of Biochemistry, University of Kashmir, Srinagar 190006, India.
Shahnaz A MirIqra Hameed, Mudasar Nabi, Khalid Ghazanfar, Department of Biochemistry, University of Kashmir, Srinagar 190006, India.
Mudasar NabiIqra Hameed, Mudasar Nabi, Khalid Ghazanfar, Department of Biochemistry, University of Kashmir, Srinagar 190006, India.
Khalid GhazanfarIqra Hameed, Mudasar Nabi, Khalid Ghazanfar, Department of Biochemistry, University of Kashmir, Srinagar 190006, India.
Bashir A GanaiIqra Hameed, Mudasar Nabi, Khalid Ghazanfar, Department of Biochemistry, University of Kashmir, Srinagar 190006, India.
University of Kashmir · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Diabetes mellitus is increasing at an alarming rate and has become a global challenge. Insulin resistance in target tissues and a relative deficiency of insulin secretion from pancreatic β-cells are the major features of type 2 diabetes (T2D). Chronic low-grade inflammation in T2D has given an impetus to the field of immuno-metabolism linking inflammation to insulin resistance and β-cell dysfunction. Many factors advocate a causal link between metabolic stress and inflammation. Numerous cellular factors trigger inflammatory signalling cascades, and as a result T2D is at the moment considered an inflammatory disorder triggered by disordered metabolism. Cellular mechanisms like activation of Toll-like receptors, Endoplasmic Reticulum stress, and inflammasome activation are related to the nutrient excess linking pathogenesis and progression of T2D with inflammation. This paper aims to systematically review the metabolic profile and role of various inflammatory pathways in T2D by capturing relevant evidence from various sources. The perspectives include suggestions for the development of therapies involving the shift from metabolic stress to homeostasis that would favour insulin sensitivity and survival of pancreatic β-cells in T2D.

Indexed as

Adipose tissueDiabetes mellitusInflammationInsulin resistanceβ-cell dysfunction

Identifiers

PMID25987957
PMCPMC4434080
OpenAlexW1486117034

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.