ReviewWorld journal of diabetes2015
Toxic stress, inflammation and symptomatology of chronic complications in diabetes.
Review in World journal of diabetes, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 41 citations in OpenAlex.
- Inflammatory Load Across Diabetes Duration: CRP and ESR Patterns and Their Metabolic Correlates.Metabolites · 2026Article
- Effect of comprehensive rehabilitation on pressure pain threshold, functional disability, and plantar pressure among type 2 diabetes mellitus individuals with chronic low back pain.Journal of back and musculoskeletal rehabilitation · 2026Article
- Impact of SGLT2 Inhibitors on Cardiovascular Risk Scores, Metabolic Parameters, and Laboratory Profiles in Type 2 Diabetes.Life (Basel, Switzerland) · 2025Article
- The Impact of Stress on Autoimmune Disorders: Type 1 Diabetes Mellitus and Systemic Lupus Erythematosus.Cureus · 2025Review
- A biobehavioural and social-structural model of inflammation and executive function in pediatric chronic health conditions.Health psychology review · 2024Article
- Urinary acrolein protein conjugates-to-creatinine ratio is positively associated with diabetic peripheral neuropathy in patients with type 2 diabetes mellitus.Endocrine connections · 2023Article
- Youth-onset type 2 diabetes mellitus: an urgent challenge.Nature reviews. Nephrology · 2023Review
- Cardiac Autonomic Neuropathy: A Progressive Consequence of Chronic Low-Grade Inflammation in Type 2 Diabetes and Related Metabolic Disorders.International journal of molecular sciences · 2020Review
- Depressive symptoms in asymptomatic stage B heart failure with Type II diabetic mellitus.Clinical cardiology · 2019Article
- Macrophage phenotype and its relationship with renal function in human diabetic nephropathy.PloS one · 2019Article
- Depressive symptoms and diabetes management from late adolescence to emerging adulthood.Health psychology : official journal of the Division of Health Psychology, American Psychological Association · 2018Article
- Relationship of Mindfulness to Distress and Cortisol Response in Adolescent Girls At-Risk for Type 2 Diabetes.Journal of child and family studies · 2018Article
- Social Determinants of Health Are Associated with Markers of Renal Injury in Adolescents with Type 1 Diabetes.The Journal of pediatrics · 2018Article
- Modulation of diabetes-related liver injury by the HMGB1/TLR4 inflammatory pathway.Journal of physiology and biochemistry · 2018Article
- Annexin A1 attenuates microvascular complications through restoration of Akt signalling in a murine model of type 1 diabetes.Diabetologia · 2018Article
- Islet transplantation attenuates cardiac fibrosis in diabetic rats through inhibition of TGF-βAmerican journal of translational research · 2018Article
- Human multipotent adult progenitor cells enhance islet function and revascularisation when co-transplanted as a composite pellet in a mouse model of diabetes.Diabetologia · 2017Article
- Indoleamine-2,3-Dioxygenase/Kynurenine Pathway as a Potential Pharmacological Target to Treat Depression Associated with Diabetes.Molecular neurobiology · 2016Article
- Involvement of the NF-κB signaling pathway in the renoprotective effects of isorhamnetin in a type 2 diabetic rat model.Biomedical reports · 2016Article
- Functional response difference between diabetic/normal cancerous patients to inflammatory cytokines and oxidative stresses after radiotherapy.Reports of practical oncology and radiotherapy : journal of Greatpoland Cancer Center in Poznan and Polish Society of Radiation OncologyReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Diabetes affects at least 382 million people worldwide and the incidence is expected to reach 592 million by 2035. The incidence of diabetes in youth is skyrocketing as evidenced by a 21% increase in type 1 diabetes and a 30.5% increase in type 2 diabetes in the United States between 2001 and 2009. The effects of toxic stress, the culmination of biological and environmental interactions, on the development of diabetes complications is gaining attention. Stress impacts the hypothalamus-pituitary-adrenal axis and contributes to inflammation, a key biological contributor to the pathogenesis of diabetes and its associated complications. This review provides an overview of common diabetic complications such as neuropathy, cognitive decline, depression, nephropathy and cardiovascular disease. The review also provides a discussion of the role of inflammation and stress in the development and progression of chronic complications of diabetes, associated symptomatology and importance of early identification of symptoms of depression, fatigue, exercise intolerance and pain.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.