ArticleInfection and immunity2015
Immunoprofiling of the tryptophan-rich antigen family in Plasmodium vivax.
Article in Infection and immunity, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 35 citations in OpenAlex.
- Proteome-wide characterization of Plasmodium vivax antigens using a high-density peptide array.PLoS pathogens · 2026Article
- Plasmodium knowlesi tryptophan-rich antigen 40.1 binds human erythrocyte spectrin alpha.PLoS neglected tropical diseases · 2026Article
- Interaction ofiScience · 2026Article
- Plasmodium vivax tryptophan-rich antigen reduces type I collagen secretion via the NF-κBp65 pathway in splenic fibroblasts.Parasites & vectors · 2024Article
- The structure of a Plasmodium vivax Tryptophan Rich Antigen domain suggests a lipid binding function for a pan-Plasmodium multi-gene family.Nature communications · 2023Article
- Polyclonal Antibody Generation against PvTRAg for the Development of a Diagnostic Assay forDiagnostics (Basel, Switzerland) · 2023Article
- Naturally acquired antibody kinetics against Plasmodium vivax antigens in people from a low malaria transmission region in western Thailand.BMC medicine · 2022Article
- Band 3-mediatedFrontiers in cellular and infection microbiology · 2022Article
- Article
- Zoonotic Malaria: Non-Pathogens (Basel, Switzerland) · 2021Review
- Dynamic Control Balancing Cell Proliferation and Inflammation is Crucial for an Effective Immune Response to Malaria.Frontiers in molecular biosciences · 2021Article
- Whole genome sequencing of Plasmodium vivax isolates reveals frequent sequence and structural polymorphisms in erythrocyte binding genes.PLoS neglected tropical diseases · 2020Article
- Development and validation of serological markers for detecting recent Plasmodium vivax infection.Nature medicine · 2020Observational
- An Erythrocyte Membrane-Associated Antigen, PvTRAg-26 ofFrontiers in public health · 2020Article
- Plasmodium genomics: an approach for learning about and ending human malaria.Parasitology research · 2019Review
- Gene Expression Profiling ofFrontiers in cellular and infection microbiology · 2019Article
- Evolutionary history of humanProceedings of the National Academy of Sciences of the United States of America · 2018Article
- Cross-species analysis of apical asparagine-rich protein of Plasmodium vivax and Plasmodium knowlesi.Scientific reports · 2018Article
- Characterization of Caveola-Vesicle Complexes (CVCs) Protein, PHIST/CVC-81The Korean journal of parasitology · 2016Article
- Article
Corrections and comments
- Erratum issued
Authors and funding
15 authors at 6 institutions in 6 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Tryptophan-rich antigens (TRAgs) are an antigen family that has been identified in human and rodent malaria parasites. TRAgs have been proposed as candidate antigens for potential vaccines. The Plasmodium vivax TRAg (PvTRAg) family includes 36 members. Each PvTRAg contains a tryptophan-rich (TR) domain in the C-terminal region. In this study, we recombinantly expressed all 36 PvTRAgs using a cell-free expression system, and, for the first time, profiled the IgG antibody responses against all PvTRAgs in the sera from 96 vivax malaria patients and 40 healthy individuals using protein microarray technology. The mean seropositive rate for all PvTRAgs was 60.3%. Among them, nine PvTRAgs were newly identified in this study and showed a seropositive rate of >50%. Five of them, PvTRAg_13, PvTRAg_15, PvTRAg_16, PvTRAg_26, and PvTRAg_29, produced higher levels of IgG antibody, even in low-endemicity countries. In addition, the results of an immunofluorescence analysis suggest that PvTRAgs are, at least in part, associated with caveola-vesicle complexes, a unique structure of P. vivax-infected erythrocytes. The mechanism of formation and the function of these abundant membrane structures are not known. Further investigation aimed at determining the functions of these proteins would lead to a better understanding of the blood-stage biology of P. vivax.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.